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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2603.16892 |
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| _version_ | 1866911523461398528 |
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| author | Shahroudi, Sharareh Parvinnasab, Amir Salahinejad, Erfan Abdi, Shaghayegh Rajabi, Sarah Tayebi, Lobat |
| author_facet | Shahroudi, Sharareh Parvinnasab, Amir Salahinejad, Erfan Abdi, Shaghayegh Rajabi, Sarah Tayebi, Lobat |
| contents | Multifunctional wound dressings with antibacterial and antioxidant properties hold significant promise for treating chronic wounds; however, achieving a balance of these characteristics while maintaining biocompatibility is challenging. To enhance this balance, this study focuses on the design and development of 3D-printed chitosan-matrix composite scaffolds, which are incorporated with varying amounts of cerium oxide nanoparticles (0, 1, 3, 5, and 7 wt%) and subsequently coated with a vancomycin-loaded alginate layer. The structure, antibiotic drug delivery kinetics, biodegradation, swelling, biocompatibility, antibacterial, antioxidant, and cell migration behaviors of the fabricated dressings were evaluated in-vitro. The findings reveal that all of the formulations demonstrated a robust antibacterial effect against S. aureus bacterial strains in disk diffusion tests. Furthermore, the dressings containing cerium oxide nanoparticles exhibited proper antioxidant capabilities, with over 78.1% reactive oxygen species (ROS) scavenging efficiency achieved with 7% cerium oxide nanoparticles. The sample containing 5% cerium oxide nanoparticles was identified as the optimal formulation, characterized by the most favorable cell biocompatibility, an ROS scavenging ability of over 73.4%, and the potential to close the wound bed within 24 h. This study highlights that these dressings are promising for managing chronic wounds by preventing infection and oxidative stress in a correct therapeutic sequence. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2603_16892 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Efficacy of 3D-Printed chitosan-cerium oxide dressings coated with vancomycin-loaded alginate for chronic wounds management Shahroudi, Sharareh Parvinnasab, Amir Salahinejad, Erfan Abdi, Shaghayegh Rajabi, Sarah Tayebi, Lobat Applied Physics Materials Science Biological Physics Medical Physics Multifunctional wound dressings with antibacterial and antioxidant properties hold significant promise for treating chronic wounds; however, achieving a balance of these characteristics while maintaining biocompatibility is challenging. To enhance this balance, this study focuses on the design and development of 3D-printed chitosan-matrix composite scaffolds, which are incorporated with varying amounts of cerium oxide nanoparticles (0, 1, 3, 5, and 7 wt%) and subsequently coated with a vancomycin-loaded alginate layer. The structure, antibiotic drug delivery kinetics, biodegradation, swelling, biocompatibility, antibacterial, antioxidant, and cell migration behaviors of the fabricated dressings were evaluated in-vitro. The findings reveal that all of the formulations demonstrated a robust antibacterial effect against S. aureus bacterial strains in disk diffusion tests. Furthermore, the dressings containing cerium oxide nanoparticles exhibited proper antioxidant capabilities, with over 78.1% reactive oxygen species (ROS) scavenging efficiency achieved with 7% cerium oxide nanoparticles. The sample containing 5% cerium oxide nanoparticles was identified as the optimal formulation, characterized by the most favorable cell biocompatibility, an ROS scavenging ability of over 73.4%, and the potential to close the wound bed within 24 h. This study highlights that these dressings are promising for managing chronic wounds by preventing infection and oxidative stress in a correct therapeutic sequence. |
| title | Efficacy of 3D-Printed chitosan-cerium oxide dressings coated with vancomycin-loaded alginate for chronic wounds management |
| topic | Applied Physics Materials Science Biological Physics Medical Physics |
| url | https://arxiv.org/abs/2603.16892 |