Less Is More in Chemotherapy of Breast Cancer
Fuente:
arXiv
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| Auteurs principaux: | , |
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| Format: | Preprint |
| Publié: |
2026
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| _version_ | 1866917350438076416 |
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| author | Ansarizadeh, Fatemeh Zhang, Tonghua |
| author_facet | Ansarizadeh, Fatemeh Zhang, Tonghua |
| contents | This study presents a mathematical model that captures the interactions among tumor cells, healthy cells, and immune cells in a tumor-bearing host, with a specific focus on breast cancer. Incorporating the concept of delay, the model consists of four differential equations to analyze these cellular dynamics. The findings demonstrate the superior efficacy of metronomic chemotherapy compared to the maximum tolerated dose (MTD) method and underscore the necessity of adjunct therapies. Oscillatory tumor cell dynamics revealed by the model highlight the challenges of achieving complete tumor elimination through chemotherapy alone. Sensitivity analysis confirms the robustness of the model, particularly under metronomic treatment protocols, aligning with experimental observations regarding metronomic-to-MTD dosage ratios. Furthermore, the results emphasize the importance of synergistic effects from combination therapies. This biologically consistent framework provides valuable insights into tumor-immune interactions and offers a foundation for optimizing therapeutic strategies in cancer treatment. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2603_16894 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Less Is More in Chemotherapy of Breast Cancer Ansarizadeh, Fatemeh Zhang, Tonghua Quantitative Methods Tissues and Organs This study presents a mathematical model that captures the interactions among tumor cells, healthy cells, and immune cells in a tumor-bearing host, with a specific focus on breast cancer. Incorporating the concept of delay, the model consists of four differential equations to analyze these cellular dynamics. The findings demonstrate the superior efficacy of metronomic chemotherapy compared to the maximum tolerated dose (MTD) method and underscore the necessity of adjunct therapies. Oscillatory tumor cell dynamics revealed by the model highlight the challenges of achieving complete tumor elimination through chemotherapy alone. Sensitivity analysis confirms the robustness of the model, particularly under metronomic treatment protocols, aligning with experimental observations regarding metronomic-to-MTD dosage ratios. Furthermore, the results emphasize the importance of synergistic effects from combination therapies. This biologically consistent framework provides valuable insights into tumor-immune interactions and offers a foundation for optimizing therapeutic strategies in cancer treatment. |
| title | Less Is More in Chemotherapy of Breast Cancer |
| topic | Quantitative Methods Tissues and Organs |
| url | https://arxiv.org/abs/2603.16894 |