Mechanical cues for totipotency and the preneural state: embryo and cancer expanding the frontiers of developmental physics
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arXiv
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| Format: | Preprint |
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2026
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| _version_ | 1866910059070488576 |
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| author | Cofre, Jaime |
| author_facet | Cofre, Jaime |
| contents | In this article, I advance the idea that physics plays a central role in cell differentiation and makes fundamental contributions to morphogenesis, revealing the totipotent nature of the zygote. Totipotency is a persistent mechanical memory that preserves the biomechanical records of animal morphogenesis. I examine the mechanical and biophysical pathways underlying cell differentiation in embryonic development and cancer, treating them as closely related biological and mechanical processes. Drawing inspiration from evolutionary history, I also propose a biophysical mechanism for the emergence of the animal nervous system. By linking physical principles to cellular differentiation, this review positions mechanobiology as a pillar of innovation with high-impact clinical implications for diseases such as cancer. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2603_18293 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Mechanical cues for totipotency and the preneural state: embryo and cancer expanding the frontiers of developmental physics Cofre, Jaime Biological Physics Medical Physics In this article, I advance the idea that physics plays a central role in cell differentiation and makes fundamental contributions to morphogenesis, revealing the totipotent nature of the zygote. Totipotency is a persistent mechanical memory that preserves the biomechanical records of animal morphogenesis. I examine the mechanical and biophysical pathways underlying cell differentiation in embryonic development and cancer, treating them as closely related biological and mechanical processes. Drawing inspiration from evolutionary history, I also propose a biophysical mechanism for the emergence of the animal nervous system. By linking physical principles to cellular differentiation, this review positions mechanobiology as a pillar of innovation with high-impact clinical implications for diseases such as cancer. |
| title | Mechanical cues for totipotency and the preneural state: embryo and cancer expanding the frontiers of developmental physics |
| topic | Biological Physics Medical Physics |
| url | https://arxiv.org/abs/2603.18293 |