Single-Subject Multi-View MRI Super-Resolution via Implicit Neural Representations

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Main Authors: Kim, Heejong, Thanki, Abhishek, van Herten, Roel, Margolis, Daniel, Sabuncu, Mert R
Format: Preprint
Published: 2026
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author Kim, Heejong
Thanki, Abhishek
van Herten, Roel
Margolis, Daniel
Sabuncu, Mert R
author_facet Kim, Heejong
Thanki, Abhishek
van Herten, Roel
Margolis, Daniel
Sabuncu, Mert R
contents Clinical MRI frequently acquires anisotropic volumes with high in-plane resolution and low through-plane resolution to reduce acquisition time. Multiple orientations are therefore acquired to provide complementary anatomical information. Conventional integration of these views relies on registration followed by interpolation, which can degrade fine structural details. Recent deep learning-based super-resolution (SR) approaches have demonstrated strong performance in enhancing single-view images. However, their clinical reliability is often limited by the need for large-scale training datasets, resulting in increased dependence on cohort-level priors. Self-supervised strategies offer an alternative by learning directly from the target scans. Prior work either neglects the existence of multi-view information or assumes that in-plane information can supervise through-plane reconstruction under the assumption of pre-alignment between images. However, this assumption is rarely satisfied in clinical settings. In this work, we introduce Single-Subject Implicit Multi-View Super-Resolution for MRI (SIMS-MRI), a framework that operates solely on anisotropic multi-view scans from a single patient without requiring pre- or post-processing. Our method combines a multi-resolution hash-encoded implicit representation with learned inter-view alignment to generate a spatially consistent isotropic reconstruction. We validate the SIMS-MRI pipeline on both simulated brain and clinical prostate MRI datasets. Code will be made publicly available for reproducibility: https://github.com/abhshkt/SIMS-MRI
format Preprint
id arxiv_https___arxiv_org_abs_2603_22627
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Single-Subject Multi-View MRI Super-Resolution via Implicit Neural Representations
Kim, Heejong
Thanki, Abhishek
van Herten, Roel
Margolis, Daniel
Sabuncu, Mert R
Image and Video Processing
Computer Vision and Pattern Recognition
Clinical MRI frequently acquires anisotropic volumes with high in-plane resolution and low through-plane resolution to reduce acquisition time. Multiple orientations are therefore acquired to provide complementary anatomical information. Conventional integration of these views relies on registration followed by interpolation, which can degrade fine structural details. Recent deep learning-based super-resolution (SR) approaches have demonstrated strong performance in enhancing single-view images. However, their clinical reliability is often limited by the need for large-scale training datasets, resulting in increased dependence on cohort-level priors. Self-supervised strategies offer an alternative by learning directly from the target scans. Prior work either neglects the existence of multi-view information or assumes that in-plane information can supervise through-plane reconstruction under the assumption of pre-alignment between images. However, this assumption is rarely satisfied in clinical settings. In this work, we introduce Single-Subject Implicit Multi-View Super-Resolution for MRI (SIMS-MRI), a framework that operates solely on anisotropic multi-view scans from a single patient without requiring pre- or post-processing. Our method combines a multi-resolution hash-encoded implicit representation with learned inter-view alignment to generate a spatially consistent isotropic reconstruction. We validate the SIMS-MRI pipeline on both simulated brain and clinical prostate MRI datasets. Code will be made publicly available for reproducibility: https://github.com/abhshkt/SIMS-MRI
title Single-Subject Multi-View MRI Super-Resolution via Implicit Neural Representations
topic Image and Video Processing
Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2603.22627