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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2603.23775 |
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| _version_ | 1866917360869310464 |
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| author | Jang, Hyun-June Nath, Peuli Wang, Yuqin Kim, Mingoo Kodam, Rohit Sai Han, Soobin Lee, Sangmin Na, Wookjin Kim, Jihoon Shi, Xiaoao Kim, Jeff J. H. Joo, HyunKeun Ryu, Byunghoon Yeo, Kiang-Teck Jerry Kee, Seung-Jung Katz, Howard E. Chen, Junhong Seok, Youngung Huh, Yun Suk Di Carlo, Dino Joung, Hyou-Arm |
| author_facet | Jang, Hyun-June Nath, Peuli Wang, Yuqin Kim, Mingoo Kodam, Rohit Sai Han, Soobin Lee, Sangmin Na, Wookjin Kim, Jihoon Shi, Xiaoao Kim, Jeff J. H. Joo, HyunKeun Ryu, Byunghoon Yeo, Kiang-Teck Jerry Kee, Seung-Jung Katz, Howard E. Chen, Junhong Seok, Youngung Huh, Yun Suk Di Carlo, Dino Joung, Hyou-Arm |
| contents | A major barrier to decentralized, near-patient diagnostics is the lack of a signal transduction modality that is both analytically precise and accessible at the point of care. Optical readouts remain instrument-dependent and difficult to miniaturize, while compact electrochemical readouts are prone to matrix-derived signal distortion, limiting their biomarker coverage in real clinical settings. Here, we define interfacial potential transduction as a standardized electrical modality for portable, clinical-grade diagnostics across diverse assay formats. A mechanistic framework identifying key sample matrix parameters within the interfacial potentials transduction system enables control of biofluid-derived interference, and is demonstrated in a widely accessible lateral flow immunoassay format through quantitative detection of estradiol, progesterone, and luteinizing hormone in human plasma with high correlation (r2 > 0.97) to clinical analyzers. Broader applicability across representative diagnostic sectors is further demonstrated through exceptional performance including glucose quantification for biochemical analysis with limit of detection (LOD) of 0.92 ug/dL, HIV p24 capsid protein under an immunomagnetic separation workflow (LOD = 44.8 fg/mL), and hepatitis B virus detection within 5 min via loop-mediated isothermal amplification for molecular diagnostics. Together, these results establish interfacial potentials transduction as a unified diagnostic paradigm for near-patient deployment beyond optical and electrochemical approaches. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2603_23775 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Interfacial Potential Transduction for Diagnostics Jang, Hyun-June Nath, Peuli Wang, Yuqin Kim, Mingoo Kodam, Rohit Sai Han, Soobin Lee, Sangmin Na, Wookjin Kim, Jihoon Shi, Xiaoao Kim, Jeff J. H. Joo, HyunKeun Ryu, Byunghoon Yeo, Kiang-Teck Jerry Kee, Seung-Jung Katz, Howard E. Chen, Junhong Seok, Youngung Huh, Yun Suk Di Carlo, Dino Joung, Hyou-Arm Biomolecules A major barrier to decentralized, near-patient diagnostics is the lack of a signal transduction modality that is both analytically precise and accessible at the point of care. Optical readouts remain instrument-dependent and difficult to miniaturize, while compact electrochemical readouts are prone to matrix-derived signal distortion, limiting their biomarker coverage in real clinical settings. Here, we define interfacial potential transduction as a standardized electrical modality for portable, clinical-grade diagnostics across diverse assay formats. A mechanistic framework identifying key sample matrix parameters within the interfacial potentials transduction system enables control of biofluid-derived interference, and is demonstrated in a widely accessible lateral flow immunoassay format through quantitative detection of estradiol, progesterone, and luteinizing hormone in human plasma with high correlation (r2 > 0.97) to clinical analyzers. Broader applicability across representative diagnostic sectors is further demonstrated through exceptional performance including glucose quantification for biochemical analysis with limit of detection (LOD) of 0.92 ug/dL, HIV p24 capsid protein under an immunomagnetic separation workflow (LOD = 44.8 fg/mL), and hepatitis B virus detection within 5 min via loop-mediated isothermal amplification for molecular diagnostics. Together, these results establish interfacial potentials transduction as a unified diagnostic paradigm for near-patient deployment beyond optical and electrochemical approaches. |
| title | Interfacial Potential Transduction for Diagnostics |
| topic | Biomolecules |
| url | https://arxiv.org/abs/2603.23775 |