Saved in:
| Main Author: | |
|---|---|
| Format: | Preprint |
| Published: |
2026
|
| Subjects: | |
| Online Access: | https://arxiv.org/abs/2603.24481 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866917361772134400 |
|---|---|
| author | Martinez, John Ray B. |
| author_facet | Martinez, John Ray B. |
| contents | Miscalibrated confidence scores are a practical obstacle to deploying AI in clinical settings. A model that is always overconfident offers no useful signal for deferral. We present a multi-agent framework that combines domain-specific specialist agents with Two-Phase Verification and S-Score Weighted Fusion to improve both calibration and discrimination in medical multiple-choice question answering. Four specialist agents (respiratory, cardiology, neurology, gastroenterology) generate independent diagnoses using Qwen2.5-7B-Instruct. Each diagnosis is then subjected to a two-phase self-verification process that measures internal consistency and produces a Specialist Confidence Score (S-score). The S-scores drive a weighted fusion strategy that selects the final answer and calibrates the reported confidence. We evaluate across four experimental settings, covering 100-question and 250-question high-disagreement subsets of both MedQA-USMLE and MedMCQA. Calibration improvement is the central finding, with ECE reduced by 49-74% across all four settings, including the harder MedMCQA benchmark where these gains persist even when absolute accuracy is constrained by knowledge-intensive recall demands. On MedQA-250, the full system achieves ECE = 0.091 (74.4% reduction over the single-specialist baseline) and AUROC = 0.630 (+0.056) at 59.2% accuracy. Ablation analysis identifies Two-Phase Verification as the primary calibration driver and multi-agent reasoning as the primary accuracy driver. These results establish that consistency-based verification produces more reliable uncertainty estimates across diverse medical question types, providing a practical confidence signal for deferral in safety-critical clinical AI applications. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2603_24481 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Multi-Agent Reasoning with Consistency Verification Improves Uncertainty Calibration in Medical MCQA Martinez, John Ray B. Artificial Intelligence Computation and Language Machine Learning Miscalibrated confidence scores are a practical obstacle to deploying AI in clinical settings. A model that is always overconfident offers no useful signal for deferral. We present a multi-agent framework that combines domain-specific specialist agents with Two-Phase Verification and S-Score Weighted Fusion to improve both calibration and discrimination in medical multiple-choice question answering. Four specialist agents (respiratory, cardiology, neurology, gastroenterology) generate independent diagnoses using Qwen2.5-7B-Instruct. Each diagnosis is then subjected to a two-phase self-verification process that measures internal consistency and produces a Specialist Confidence Score (S-score). The S-scores drive a weighted fusion strategy that selects the final answer and calibrates the reported confidence. We evaluate across four experimental settings, covering 100-question and 250-question high-disagreement subsets of both MedQA-USMLE and MedMCQA. Calibration improvement is the central finding, with ECE reduced by 49-74% across all four settings, including the harder MedMCQA benchmark where these gains persist even when absolute accuracy is constrained by knowledge-intensive recall demands. On MedQA-250, the full system achieves ECE = 0.091 (74.4% reduction over the single-specialist baseline) and AUROC = 0.630 (+0.056) at 59.2% accuracy. Ablation analysis identifies Two-Phase Verification as the primary calibration driver and multi-agent reasoning as the primary accuracy driver. These results establish that consistency-based verification produces more reliable uncertainty estimates across diverse medical question types, providing a practical confidence signal for deferral in safety-critical clinical AI applications. |
| title | Multi-Agent Reasoning with Consistency Verification Improves Uncertainty Calibration in Medical MCQA |
| topic | Artificial Intelligence Computation and Language Machine Learning |
| url | https://arxiv.org/abs/2603.24481 |