Multimodal Higher-Order Brain Networks: A Topological Signal Processing Perspective
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arXiv
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| Auteurs principaux: | , , , |
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| Format: | Preprint |
| Publié: |
2026
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| _version_ | 1866908926776180736 |
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| author | Bispo, Breno C. Sardellitti, Stefania Lima, Juliano B. Santos, Fernando A. N. |
| author_facet | Bispo, Breno C. Sardellitti, Stefania Lima, Juliano B. Santos, Fernando A. N. |
| contents | Brain connectomics is still largely dominated by pairwise-based models, such as graphs, which cannot represent circulatory or higher-order functional interactions. In this paper, we propose a multimodal framework based on Topological Signal Processing (TSP) that models the brain as a higher-order topological domain and treats functional interactions as discrete vector fields. We integrate diffusion MRI and resting-state fMRI to learn subject-specific brain cell complexes, where statistically validated structural connectivity defines a sparse scaffold and phase-coupling functional edge signals drive the inference of higher-order interactions (HOIs). Using Hodge-theoretic tools, spectral filtering, and sparse signal representations, our framework disentangles brain connectivity into divergence (source-sink organization), gradient (potential-driven coordination), and curl (circulatory HOIs), enabling the characterization of temporal dynamics through the lens of discrete vector calculus. Across 100 healthy young adults from Human Connectome Project, node-based HOIs are highly individualized, yet robust mesoscale structure emerges under functional-system aggregation. We identify a distributed default mode network-centered gradient backbone and limbic-centered rotational flows; divergence polarization and curl profiles defining circulation regimes with insightful occupancy and dwell-time statistics. These topological signatures yield significant brain-behavior associations, revealing a relevant higher-order organization intrinsic to edge-based models. By making divergence, circulation, and recurrent mesoscale coordination directly measurable, this work enables a principled and interpretable topological phenotyping of brain function. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2603_29903 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Multimodal Higher-Order Brain Networks: A Topological Signal Processing Perspective Bispo, Breno C. Sardellitti, Stefania Lima, Juliano B. Santos, Fernando A. N. Neurons and Cognition Signal Processing Brain connectomics is still largely dominated by pairwise-based models, such as graphs, which cannot represent circulatory or higher-order functional interactions. In this paper, we propose a multimodal framework based on Topological Signal Processing (TSP) that models the brain as a higher-order topological domain and treats functional interactions as discrete vector fields. We integrate diffusion MRI and resting-state fMRI to learn subject-specific brain cell complexes, where statistically validated structural connectivity defines a sparse scaffold and phase-coupling functional edge signals drive the inference of higher-order interactions (HOIs). Using Hodge-theoretic tools, spectral filtering, and sparse signal representations, our framework disentangles brain connectivity into divergence (source-sink organization), gradient (potential-driven coordination), and curl (circulatory HOIs), enabling the characterization of temporal dynamics through the lens of discrete vector calculus. Across 100 healthy young adults from Human Connectome Project, node-based HOIs are highly individualized, yet robust mesoscale structure emerges under functional-system aggregation. We identify a distributed default mode network-centered gradient backbone and limbic-centered rotational flows; divergence polarization and curl profiles defining circulation regimes with insightful occupancy and dwell-time statistics. These topological signatures yield significant brain-behavior associations, revealing a relevant higher-order organization intrinsic to edge-based models. By making divergence, circulation, and recurrent mesoscale coordination directly measurable, this work enables a principled and interpretable topological phenotyping of brain function. |
| title | Multimodal Higher-Order Brain Networks: A Topological Signal Processing Perspective |
| topic | Neurons and Cognition Signal Processing |
| url | https://arxiv.org/abs/2603.29903 |