Renal Blood Flow Quantification During Standard Myocardial Perfusion Imaging with Rubidium-82 Positron Emission Tomography
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arXiv
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| Natura: | Preprint |
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2026
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| author | Abdollahi, Hamid Doot, Robert Porto, Raul Young, Anthony Tahari, Abdel K Townsend, Raymond Dubroff, Jacob Rahmim, Arman Bravo, Paco E. |
| author_facet | Abdollahi, Hamid Doot, Robert Porto, Raul Young, Anthony Tahari, Abdel K Townsend, Raymond Dubroff, Jacob Rahmim, Arman Bravo, Paco E. |
| contents | Background: Renal blood flow (RBF) is an important marker of kidney health, but noninvasive assessment is not routinely used in clinical imaging. We evaluated the feasibility and physiologic validity of quantifying renal transport of Rubidium-82 (K1) during standard myocardial perfusion imaging (MPI) PET. Methods: We studied 126 patients (age 60 +/- 12 years; 48% male; 51% Black) undergoing clinically indicated rest and stress Rb-82 MPI, in whom at least one kidney was partially visualized within the axial field of view. Volumes of interest were drawn over the visible renal cortex. K1 was estimated using a one-tissue compartment model with arterial input functions (AIF) derived from either the left ventricle (LV) or abdominal aorta. Results: LV-derived AIF produced physiologic and internally consistent flow estimates, whereas aorta-derived AIF systematically overestimated K1 and flow. LV-based measurements were therefore used for all analyses. K1 demonstrated nonlinear flow dependence consistent with the Renkin-Crone extraction model, plateauing at higher perfusion states. Renal K1 and flow declined progressively with worsening kidney function, from 1.24 +/- 0.35 ml/min/g (eGFR >= 60) to 0.53 +/- 0.22 ml/min/g (eGFR < 15; P < 0.0001). Only patients with preserved eGFR showed significant hyperemic augmentation. ROC analysis demonstrated excellent discrimination for reduced kidney function (AUC > 0.90). Conclusion: Opportunistic renal K1 quantification during routine Rb-82 PET is feasible, physiologically consistent, and strongly associated with kidney function. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2603_30005 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Renal Blood Flow Quantification During Standard Myocardial Perfusion Imaging with Rubidium-82 Positron Emission Tomography Abdollahi, Hamid Doot, Robert Porto, Raul Young, Anthony Tahari, Abdel K Townsend, Raymond Dubroff, Jacob Rahmim, Arman Bravo, Paco E. Medical Physics Background: Renal blood flow (RBF) is an important marker of kidney health, but noninvasive assessment is not routinely used in clinical imaging. We evaluated the feasibility and physiologic validity of quantifying renal transport of Rubidium-82 (K1) during standard myocardial perfusion imaging (MPI) PET. Methods: We studied 126 patients (age 60 +/- 12 years; 48% male; 51% Black) undergoing clinically indicated rest and stress Rb-82 MPI, in whom at least one kidney was partially visualized within the axial field of view. Volumes of interest were drawn over the visible renal cortex. K1 was estimated using a one-tissue compartment model with arterial input functions (AIF) derived from either the left ventricle (LV) or abdominal aorta. Results: LV-derived AIF produced physiologic and internally consistent flow estimates, whereas aorta-derived AIF systematically overestimated K1 and flow. LV-based measurements were therefore used for all analyses. K1 demonstrated nonlinear flow dependence consistent with the Renkin-Crone extraction model, plateauing at higher perfusion states. Renal K1 and flow declined progressively with worsening kidney function, from 1.24 +/- 0.35 ml/min/g (eGFR >= 60) to 0.53 +/- 0.22 ml/min/g (eGFR < 15; P < 0.0001). Only patients with preserved eGFR showed significant hyperemic augmentation. ROC analysis demonstrated excellent discrimination for reduced kidney function (AUC > 0.90). Conclusion: Opportunistic renal K1 quantification during routine Rb-82 PET is feasible, physiologically consistent, and strongly associated with kidney function. |
| title | Renal Blood Flow Quantification During Standard Myocardial Perfusion Imaging with Rubidium-82 Positron Emission Tomography |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2603.30005 |