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Main Authors: Bezek, Can Deniz, Goksel, Orcun
Format: Preprint
Published: 2026
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Online Access:https://arxiv.org/abs/2604.02105
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author Bezek, Can Deniz
Goksel, Orcun
author_facet Bezek, Can Deniz
Goksel, Orcun
contents Medical imaging aims to recover underlying tissue properties, using inexact (simplified/linearized) imaging models and often from inaccurate and incomplete measurements. Analytical reconstruction methods rely on hand-crafted regularization, sensitive to noise assumptions and parameter tuning. Among deep learning alternatives, plug-and-play (PnP) approaches learn regularization while incorporating imaging physics during inference, outperforming purely data-driven methods. The performance of all these approaches, however, still strongly depends on measurement quality and imaging model accuracy. In this work, we propose DenOiS, a framework that denoises both input observations and resulting solution in their respective domains. It consists of an observation refinement strategy that corrects degraded measurements while compensating for imaging model simplifications, and a diffusion-based PnP reconstruction approach that remains robust under missing measurements. DenOiS enables generalization to real data from training only in simulations, resulting in high-fidelity image reconstruction with noisy observations and inexact imaging models. We demonstrate this for speed-of-sound imaging as a challenging setting of quantitative ultrasound image reconstruction.
format Preprint
id arxiv_https___arxiv_org_abs_2604_02105
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle DenOiS: Dual-Domain Denoising of Observation and Solution in Ultrasound Image Reconstruction
Bezek, Can Deniz
Goksel, Orcun
Image and Video Processing
Computer Vision and Pattern Recognition
Medical imaging aims to recover underlying tissue properties, using inexact (simplified/linearized) imaging models and often from inaccurate and incomplete measurements. Analytical reconstruction methods rely on hand-crafted regularization, sensitive to noise assumptions and parameter tuning. Among deep learning alternatives, plug-and-play (PnP) approaches learn regularization while incorporating imaging physics during inference, outperforming purely data-driven methods. The performance of all these approaches, however, still strongly depends on measurement quality and imaging model accuracy. In this work, we propose DenOiS, a framework that denoises both input observations and resulting solution in their respective domains. It consists of an observation refinement strategy that corrects degraded measurements while compensating for imaging model simplifications, and a diffusion-based PnP reconstruction approach that remains robust under missing measurements. DenOiS enables generalization to real data from training only in simulations, resulting in high-fidelity image reconstruction with noisy observations and inexact imaging models. We demonstrate this for speed-of-sound imaging as a challenging setting of quantitative ultrasound image reconstruction.
title DenOiS: Dual-Domain Denoising of Observation and Solution in Ultrasound Image Reconstruction
topic Image and Video Processing
Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2604.02105