Guideline2Graph: Profile-Aware Multimodal Parsing for Executable Clinical Decision Graphs

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Auteurs principaux: Kilic, Onur Selim, Gurbuz, Yeti Z., Yaldiz, Cem O., Nawar, Afra, Haxholli, Etrit, Can, Ogul, Waxman, Eli
Format: Preprint
Publié: 2026
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author Kilic, Onur Selim
Gurbuz, Yeti Z.
Yaldiz, Cem O.
Nawar, Afra
Haxholli, Etrit
Can, Ogul
Waxman, Eli
author_facet Kilic, Onur Selim
Gurbuz, Yeti Z.
Yaldiz, Cem O.
Nawar, Afra
Haxholli, Etrit
Can, Ogul
Waxman, Eli
contents Clinical practice guidelines are long, multimodal documents whose branching recommendations are difficult to convert into executable clinical decision support (CDS), and one-shot parsing often breaks cross-page continuity. Recent LLM/VLM extractors are mostly local or text-centric, under-specifying section interfaces and failing to consolidate cross-page control flow across full documents into one coherent decision graph. We present a decomposition-first pipeline that converts full-guideline evidence into an executable clinical decision graph through topology-aware chunking, interface-constrained chunk graph generation, and provenance-preserving global aggregation. Rather than relying on single-pass generation, the pipeline uses explicit entry/terminal interfaces and semantic deduplication to preserve cross-page continuity while keeping the induced control flow auditable and structurally consistent. We evaluate on an adjudicated prostate-guideline benchmark with matched inputs and the same underlying VLM backbone across compared methods. On the complete merged graph, our approach improves edge and triplet precision/recall from $19.6\%/16.1\%$ in existing models to $69.0\%/87.5\%$, while node recall rises from $78.1\%$ to $93.8\%$. These results support decomposition-first, auditable guideline-to-CDS conversion on this benchmark, while current evidence remains limited to one adjudicated prostate guideline and motivates broader multi-guideline validation.
format Preprint
id arxiv_https___arxiv_org_abs_2604_02477
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Guideline2Graph: Profile-Aware Multimodal Parsing for Executable Clinical Decision Graphs
Kilic, Onur Selim
Gurbuz, Yeti Z.
Yaldiz, Cem O.
Nawar, Afra
Haxholli, Etrit
Can, Ogul
Waxman, Eli
Computer Vision and Pattern Recognition
Machine Learning
Clinical practice guidelines are long, multimodal documents whose branching recommendations are difficult to convert into executable clinical decision support (CDS), and one-shot parsing often breaks cross-page continuity. Recent LLM/VLM extractors are mostly local or text-centric, under-specifying section interfaces and failing to consolidate cross-page control flow across full documents into one coherent decision graph. We present a decomposition-first pipeline that converts full-guideline evidence into an executable clinical decision graph through topology-aware chunking, interface-constrained chunk graph generation, and provenance-preserving global aggregation. Rather than relying on single-pass generation, the pipeline uses explicit entry/terminal interfaces and semantic deduplication to preserve cross-page continuity while keeping the induced control flow auditable and structurally consistent. We evaluate on an adjudicated prostate-guideline benchmark with matched inputs and the same underlying VLM backbone across compared methods. On the complete merged graph, our approach improves edge and triplet precision/recall from $19.6\%/16.1\%$ in existing models to $69.0\%/87.5\%$, while node recall rises from $78.1\%$ to $93.8\%$. These results support decomposition-first, auditable guideline-to-CDS conversion on this benchmark, while current evidence remains limited to one adjudicated prostate guideline and motivates broader multi-guideline validation.
title Guideline2Graph: Profile-Aware Multimodal Parsing for Executable Clinical Decision Graphs
topic Computer Vision and Pattern Recognition
Machine Learning
url https://arxiv.org/abs/2604.02477