Overconfidence and Calibration in Medical VQA: Empirical Findings and Hallucination-Aware Mitigation

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Auteurs principaux: Byun, Ji Young, Park, Young-Jin, Corbeil, Jean-Philippe, Abacha, Asma Ben
Format: Preprint
Publié: 2026
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author Byun, Ji Young
Park, Young-Jin
Corbeil, Jean-Philippe
Abacha, Asma Ben
author_facet Byun, Ji Young
Park, Young-Jin
Corbeil, Jean-Philippe
Abacha, Asma Ben
contents As vision-language models (VLMs) are increasingly deployed in clinical decision support, more than accuracy is required: knowing when to trust their predictions is equally critical. Yet, a comprehensive and systematic investigation into the overconfidence of these models remains notably scarce in the medical domain. We address this gap through a comprehensive empirical study of confidence calibration in VLMs, spanning three model families (Qwen3-VL, InternVL3, LLaVA-NeXT), three model scales (2B--38B), and multiple confidence estimation prompting strategies, across three medical visual question answering (VQA) benchmarks. Our study yields three key findings: First, overconfidence persists across model families and is not resolved by scaling or prompting, such as chain-of-thought and verbalized confidence variants. Second, simple post-hoc calibration approaches, such as Platt scaling, reduce calibration error and consistently outperform the prompt-based strategy. Third, due to their (strict) monotonicity, these post-hoc calibration methods are inherently limited in improving the discriminative quality of predictions, leaving AUROC at the same level. Motivated by these findings, we investigate hallucination-aware calibration (HAC), which incorporates vision-grounded hallucination detection signals as complementary inputs to refine confidence estimates. We find that leveraging these hallucination signals improves both calibration and AUROC, with the largest gains on open-ended questions. Overall, our findings suggest post-hoc calibration as standard practice for medical VLM deployment over raw confidence estimates, and highlight the practical usefulness of hallucination signals to enable more reliable use of VLMs in medical VQA.
format Preprint
id arxiv_https___arxiv_org_abs_2604_02543
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Overconfidence and Calibration in Medical VQA: Empirical Findings and Hallucination-Aware Mitigation
Byun, Ji Young
Park, Young-Jin
Corbeil, Jean-Philippe
Abacha, Asma Ben
Computer Vision and Pattern Recognition
Machine Learning
As vision-language models (VLMs) are increasingly deployed in clinical decision support, more than accuracy is required: knowing when to trust their predictions is equally critical. Yet, a comprehensive and systematic investigation into the overconfidence of these models remains notably scarce in the medical domain. We address this gap through a comprehensive empirical study of confidence calibration in VLMs, spanning three model families (Qwen3-VL, InternVL3, LLaVA-NeXT), three model scales (2B--38B), and multiple confidence estimation prompting strategies, across three medical visual question answering (VQA) benchmarks. Our study yields three key findings: First, overconfidence persists across model families and is not resolved by scaling or prompting, such as chain-of-thought and verbalized confidence variants. Second, simple post-hoc calibration approaches, such as Platt scaling, reduce calibration error and consistently outperform the prompt-based strategy. Third, due to their (strict) monotonicity, these post-hoc calibration methods are inherently limited in improving the discriminative quality of predictions, leaving AUROC at the same level. Motivated by these findings, we investigate hallucination-aware calibration (HAC), which incorporates vision-grounded hallucination detection signals as complementary inputs to refine confidence estimates. We find that leveraging these hallucination signals improves both calibration and AUROC, with the largest gains on open-ended questions. Overall, our findings suggest post-hoc calibration as standard practice for medical VLM deployment over raw confidence estimates, and highlight the practical usefulness of hallucination signals to enable more reliable use of VLMs in medical VQA.
title Overconfidence and Calibration in Medical VQA: Empirical Findings and Hallucination-Aware Mitigation
topic Computer Vision and Pattern Recognition
Machine Learning
url https://arxiv.org/abs/2604.02543