SD-FSMIS: Adapting Stable Diffusion for Few-Shot Medical Image Segmentation

Fuente: arXiv
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Autori principali: Li, Meihua, Zhang, Yang, He, Weizhao, Qu, Hu, Li, Yisong
Natura: Preprint
Pubblicazione: 2026
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author Li, Meihua
Zhang, Yang
He, Weizhao
Qu, Hu
Li, Yisong
author_facet Li, Meihua
Zhang, Yang
He, Weizhao
Qu, Hu
Li, Yisong
contents Few-Shot Medical Image Segmentation (FSMIS) aims to segment novel object classes in medical images using only minimal annotated examples, addressing the critical challenges of data scarcity and domain shifts prevalent in medical imaging. While Diffusion Models (DM) excel in visual tasks, their potential for FSMIS remains largely unexplored. We propose that the rich visual priors learned by large-scale DMs offer a powerful foundation for a more robust and data-efficient segmentation approach. In this paper, we introduce SD-FSMIS, a novel framework designed to effectively adapt the powerful pre-trained Stable Diffusion (SD) model for the FSMIS task. Our approach repurposes its conditional generative architecture by introducing two key components: a Support-Query Interaction (SQI) and a Visual-to-Textual Condition Translator (VTCT). Specifically, SQI provides a straightforward yet powerful means of adapting SD to the FSMIS paradigm. The VTCT module translates visual cues from the support set into an implicit textual embedding that guides the diffusion model, enabling precise conditioning of the generation process. Extensive experiments demonstrate that SD-FSMIS achieves competitive results compared to state-of-the-art methods in standard settings. Surprisingly, it also demonstrated excellent generalization ability in more challenging cross-domain scenarios. These findings highlight the immense potential of adapting large-scale generative models to advance data-efficient and robust medical image segmentation.
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id arxiv_https___arxiv_org_abs_2604_03134
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publishDate 2026
record_format arxiv
spellingShingle SD-FSMIS: Adapting Stable Diffusion for Few-Shot Medical Image Segmentation
Li, Meihua
Zhang, Yang
He, Weizhao
Qu, Hu
Li, Yisong
Computer Vision and Pattern Recognition
Few-Shot Medical Image Segmentation (FSMIS) aims to segment novel object classes in medical images using only minimal annotated examples, addressing the critical challenges of data scarcity and domain shifts prevalent in medical imaging. While Diffusion Models (DM) excel in visual tasks, their potential for FSMIS remains largely unexplored. We propose that the rich visual priors learned by large-scale DMs offer a powerful foundation for a more robust and data-efficient segmentation approach. In this paper, we introduce SD-FSMIS, a novel framework designed to effectively adapt the powerful pre-trained Stable Diffusion (SD) model for the FSMIS task. Our approach repurposes its conditional generative architecture by introducing two key components: a Support-Query Interaction (SQI) and a Visual-to-Textual Condition Translator (VTCT). Specifically, SQI provides a straightforward yet powerful means of adapting SD to the FSMIS paradigm. The VTCT module translates visual cues from the support set into an implicit textual embedding that guides the diffusion model, enabling precise conditioning of the generation process. Extensive experiments demonstrate that SD-FSMIS achieves competitive results compared to state-of-the-art methods in standard settings. Surprisingly, it also demonstrated excellent generalization ability in more challenging cross-domain scenarios. These findings highlight the immense potential of adapting large-scale generative models to advance data-efficient and robust medical image segmentation.
title SD-FSMIS: Adapting Stable Diffusion for Few-Shot Medical Image Segmentation
topic Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2604.03134