Haematocrit and Shear Rate Modulate Local Cell-free Layer Thickness and Platelet Margination in Blood Flow Along a Sinusoidal Wall
Fuente:
arXiv
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Preprint |
| Veröffentlicht: |
2026
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1866911571899318272 |
|---|---|
| author | Pero, Eleonora Tomaiuolo, Giovanna Guido, Stefano Denham, Claire Krueger, Timm |
| author_facet | Pero, Eleonora Tomaiuolo, Giovanna Guido, Stefano Denham, Claire Krueger, Timm |
| contents | The geometry of blood vessels strongly affects hemostasis and thrombosis through red blood cell (RBC) dynamics and platelet margination. Growing platelet aggregates, in turn, reshape the local vessel wall topography, leading to a strongly coupled system. However, it is not well understood how surface heterogeneities alter local hemodynamics and platelet margination, thereby driving further aggregate growth. This study investigates how hematocrit (Ht) and shear rate affect RBC dynamics, cell-free layer (CFL) thickness, and platelet margination near a sinusoidal wall. The sinusoidal wall, with crests and valleys aligned with the flow direction, serves as a model of the flow-aligned platelet aggregates observed in microfluidic experiments [Pero et al., CRPS, 2024]. We perform three-dimensional immersed-boundary-lattice-Boltzmann simulations of particulate blood flow with deformable RBCs and nearly rigid spherical platelets. Our results show that platelet margination is primarily governed by Ht and is more pronounced in regions where the CFL thickness is similar to the platelet size. At low Ht, platelets preferentially accumulate at crests, promoting high-amplitude aggregate growth. Increasing Ht leads to a more uniform platelet distribution along the surface, consistent with experimental observations. The sinusoidal geometry generates a pronounced crest-valley wall shear rate gradient, suggesting that distinct shear-dependent adhesion pathways may dominate at different surface locations. Our findings provide mechanistic insights into the morphological evolution of platelet aggregates and may ultimately inform targeted therapeutic strategies for thrombosis based on shear-sensitive drug-delivery. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2604_05573 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Haematocrit and Shear Rate Modulate Local Cell-free Layer Thickness and Platelet Margination in Blood Flow Along a Sinusoidal Wall Pero, Eleonora Tomaiuolo, Giovanna Guido, Stefano Denham, Claire Krueger, Timm Fluid Dynamics Biological Physics Tissues and Organs The geometry of blood vessels strongly affects hemostasis and thrombosis through red blood cell (RBC) dynamics and platelet margination. Growing platelet aggregates, in turn, reshape the local vessel wall topography, leading to a strongly coupled system. However, it is not well understood how surface heterogeneities alter local hemodynamics and platelet margination, thereby driving further aggregate growth. This study investigates how hematocrit (Ht) and shear rate affect RBC dynamics, cell-free layer (CFL) thickness, and platelet margination near a sinusoidal wall. The sinusoidal wall, with crests and valleys aligned with the flow direction, serves as a model of the flow-aligned platelet aggregates observed in microfluidic experiments [Pero et al., CRPS, 2024]. We perform three-dimensional immersed-boundary-lattice-Boltzmann simulations of particulate blood flow with deformable RBCs and nearly rigid spherical platelets. Our results show that platelet margination is primarily governed by Ht and is more pronounced in regions where the CFL thickness is similar to the platelet size. At low Ht, platelets preferentially accumulate at crests, promoting high-amplitude aggregate growth. Increasing Ht leads to a more uniform platelet distribution along the surface, consistent with experimental observations. The sinusoidal geometry generates a pronounced crest-valley wall shear rate gradient, suggesting that distinct shear-dependent adhesion pathways may dominate at different surface locations. Our findings provide mechanistic insights into the morphological evolution of platelet aggregates and may ultimately inform targeted therapeutic strategies for thrombosis based on shear-sensitive drug-delivery. |
| title | Haematocrit and Shear Rate Modulate Local Cell-free Layer Thickness and Platelet Margination in Blood Flow Along a Sinusoidal Wall |
| topic | Fluid Dynamics Biological Physics Tissues and Organs |
| url | https://arxiv.org/abs/2604.05573 |