Inference-Sufficient Representations for High-Throughput Measurement: Lessons from Lossless Compression Benchmarks in 4D-STEM

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Hauptverfasser: Dyck, Ondrej, Lupini, Andrew R., Borisevich, Albina, Chi, Miaofang, Vasudevan, Rama K., Jesse, Stephen
Format: Preprint
Veröffentlicht: 2026
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author Dyck, Ondrej
Lupini, Andrew R.
Borisevich, Albina
Chi, Miaofang
Vasudevan, Rama K.
Jesse, Stephen
author_facet Dyck, Ondrej
Lupini, Andrew R.
Borisevich, Albina
Chi, Miaofang
Vasudevan, Rama K.
Jesse, Stephen
contents Four-dimensional scanning transmission electron microscopy (4D-STEM) generates multi-gigabyte datasets, creating a growing mismatch between acquisition rates and practical storage, transfer, and interactive visualization capabilities. We systematically benchmark 13 lossless compression implementations across 5 representative datasets (8~MiB to 8~GiB, 49.5--92.8\% sparsity), with 10 independent runs per method. HDF5 provides built-in gzip compression, of which gzip-9 typically achieves the highest compression ratio but is slow. We therefore evaluate widely available alternatives (via hdf5plugin), including the Blosc family. As a representative comparison, blosc\_zstd achieves compression comparable to gzip-9 (mean 13.5$\times$ vs 12.3$\times$) while compressing 19--69$\times$ faster and reading 1.9--2.6$\times$ faster across datasets. Compression ratios are deterministic, and timing measurements are highly reproducible (CV $<$2\%). Compression performance follows a power law with sparsity ($R^2 = 0.99$), ranging from 5$\times$ for moderately sparse data to 35$\times$ for highly sparse data. We identify six top-performing implementations optimized for different use cases and demonstrate that 4D-STEM data can be routinely compressed by $>$10$\times$. While these results provide practical guidance for lossless compression selection, the broader conclusion is that lossless compression preserves measurements but does not by itself guarantee sustainable high-throughput workflows. As detector rates rise, data handling will increasingly require inference-driven representations -- i.e., deciding what must be preserved to support a scientific inference, rather than defaulting to storing fully dense raw measurements.
format Preprint
id arxiv_https___arxiv_org_abs_2604_06221
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Inference-Sufficient Representations for High-Throughput Measurement: Lessons from Lossless Compression Benchmarks in 4D-STEM
Dyck, Ondrej
Lupini, Andrew R.
Borisevich, Albina
Chi, Miaofang
Vasudevan, Rama K.
Jesse, Stephen
Signal Processing
Materials Science
Four-dimensional scanning transmission electron microscopy (4D-STEM) generates multi-gigabyte datasets, creating a growing mismatch between acquisition rates and practical storage, transfer, and interactive visualization capabilities. We systematically benchmark 13 lossless compression implementations across 5 representative datasets (8~MiB to 8~GiB, 49.5--92.8\% sparsity), with 10 independent runs per method. HDF5 provides built-in gzip compression, of which gzip-9 typically achieves the highest compression ratio but is slow. We therefore evaluate widely available alternatives (via hdf5plugin), including the Blosc family. As a representative comparison, blosc\_zstd achieves compression comparable to gzip-9 (mean 13.5$\times$ vs 12.3$\times$) while compressing 19--69$\times$ faster and reading 1.9--2.6$\times$ faster across datasets. Compression ratios are deterministic, and timing measurements are highly reproducible (CV $<$2\%). Compression performance follows a power law with sparsity ($R^2 = 0.99$), ranging from 5$\times$ for moderately sparse data to 35$\times$ for highly sparse data. We identify six top-performing implementations optimized for different use cases and demonstrate that 4D-STEM data can be routinely compressed by $>$10$\times$. While these results provide practical guidance for lossless compression selection, the broader conclusion is that lossless compression preserves measurements but does not by itself guarantee sustainable high-throughput workflows. As detector rates rise, data handling will increasingly require inference-driven representations -- i.e., deciding what must be preserved to support a scientific inference, rather than defaulting to storing fully dense raw measurements.
title Inference-Sufficient Representations for High-Throughput Measurement: Lessons from Lossless Compression Benchmarks in 4D-STEM
topic Signal Processing
Materials Science
url https://arxiv.org/abs/2604.06221