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| Autori principali: | , , , , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2026
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| Soggetti: | |
| Accesso online: | https://arxiv.org/abs/2604.08225 |
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| _version_ | 1866911578542047232 |
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| author | Occhicone, Agostino Sinibaldi, Alberto Munzert, Peter Butt, Jordan N. Luta, Ethan P. Arévalo, Diego M. Michelotti, Francesco Miller, Benjamin L. |
| author_facet | Occhicone, Agostino Sinibaldi, Alberto Munzert, Peter Butt, Jordan N. Luta, Ethan P. Arévalo, Diego M. Michelotti, Francesco Miller, Benjamin L. |
| contents | This study presents a rigorous comparative analysis of two label-free optical biosensing platforms, Bloch surface wave (BSW) and microring resonator (MRR), for the detection of SARS-CoV-2 antibodies in human serum. To ensure direct comparability, a new BSW readout system was established alongside an existing MRR platform, allowing assays to be conducted under nearly identical experimental conditions. Both sensors were functionalized with various SARS-CoV-2 Spike and Nucleocapsid protein variants to capture specific host antibodies. The results demonstrate that both platforms provide rapid, quantitative, and sensitive detection of anti-Spike and anti-Nucleocapsid antibodies without the need for secondary labels. Furthermore, the platforms show excellent agreement with longitudinal serology benchmarks and high repeatability across different biochip batches. This work establishes both BSW and MRR technologies as powerful, low-cost candidates for next-generation clinical diagnostics and serological surveillance. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2604_08225 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Comparative performance of three optical biosensing platforms for SARS-CoV-2 antibodies detection in human serum Occhicone, Agostino Sinibaldi, Alberto Munzert, Peter Butt, Jordan N. Luta, Ethan P. Arévalo, Diego M. Michelotti, Francesco Miller, Benjamin L. Optics Materials Science Soft Condensed Matter Biological Physics This study presents a rigorous comparative analysis of two label-free optical biosensing platforms, Bloch surface wave (BSW) and microring resonator (MRR), for the detection of SARS-CoV-2 antibodies in human serum. To ensure direct comparability, a new BSW readout system was established alongside an existing MRR platform, allowing assays to be conducted under nearly identical experimental conditions. Both sensors were functionalized with various SARS-CoV-2 Spike and Nucleocapsid protein variants to capture specific host antibodies. The results demonstrate that both platforms provide rapid, quantitative, and sensitive detection of anti-Spike and anti-Nucleocapsid antibodies without the need for secondary labels. Furthermore, the platforms show excellent agreement with longitudinal serology benchmarks and high repeatability across different biochip batches. This work establishes both BSW and MRR technologies as powerful, low-cost candidates for next-generation clinical diagnostics and serological surveillance. |
| title | Comparative performance of three optical biosensing platforms for SARS-CoV-2 antibodies detection in human serum |
| topic | Optics Materials Science Soft Condensed Matter Biological Physics |
| url | https://arxiv.org/abs/2604.08225 |