Controlled beams of cryo-cooled protein-like nanoparticles
Fuente:
arXiv
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| Autori principali: | , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2026
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| Soggetti: | |
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| _version_ | 1866915929857720320 |
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| author | He, Jingxuan Długołecki, Karol Bromberger, Hubertus Samanta, Amit K. Küpper, Jochen |
| author_facet | He, Jingxuan Długołecki, Karol Bromberger, Hubertus Samanta, Amit K. Küpper, Jochen |
| contents | We report a cryogenic buffer-gas-cell-aerodynamic-lens-stack setup that enables the generation of shock-frozen, dense, and controllable beams of various nanoparticles in the gas phase, including small and low-density species such as isolated proteins. We demonstrate characterization of the setup using strong-field ionization combined with velocity-map imaging, allowing the unambiguous detection of nanoparticles in the protein-size range and full reconstruction of the particle beams including determination of particle flux and number density. The generation and characterization workflow presented here provides a valuable approach for protein-like sample preparation and delivery in single-particle diffractive imaging, microscopy, and low-temperature nanoscience. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2604_09090 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Controlled beams of cryo-cooled protein-like nanoparticles He, Jingxuan Długołecki, Karol Bromberger, Hubertus Samanta, Amit K. Küpper, Jochen Instrumentation and Detectors We report a cryogenic buffer-gas-cell-aerodynamic-lens-stack setup that enables the generation of shock-frozen, dense, and controllable beams of various nanoparticles in the gas phase, including small and low-density species such as isolated proteins. We demonstrate characterization of the setup using strong-field ionization combined with velocity-map imaging, allowing the unambiguous detection of nanoparticles in the protein-size range and full reconstruction of the particle beams including determination of particle flux and number density. The generation and characterization workflow presented here provides a valuable approach for protein-like sample preparation and delivery in single-particle diffractive imaging, microscopy, and low-temperature nanoscience. |
| title | Controlled beams of cryo-cooled protein-like nanoparticles |
| topic | Instrumentation and Detectors |
| url | https://arxiv.org/abs/2604.09090 |