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Main Authors: Ning, Junzhi, Lin, Jiashi, Fang, Yingying, Li, Wei, Liu, Jiyao, Tang, Cheng, Ma, Chenglong, Tang, Wenhao, Li, Tianbin, Huang, Ziyan, Yang, Guang, He, Junjun
Format: Preprint
Published: 2026
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Online Access:https://arxiv.org/abs/2604.10755
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author Ning, Junzhi
Lin, Jiashi
Fang, Yingying
Li, Wei
Liu, Jiyao
Tang, Cheng
Ma, Chenglong
Tang, Wenhao
Li, Tianbin
Huang, Ziyan
Yang, Guang
He, Junjun
author_facet Ning, Junzhi
Lin, Jiashi
Fang, Yingying
Li, Wei
Liu, Jiyao
Tang, Cheng
Ma, Chenglong
Tang, Wenhao
Li, Tianbin
Huang, Ziyan
Yang, Guang
He, Junjun
contents Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing them to rely strictly on case-level evidence for clinical judgments. Existing benchmarks predominantly evaluate common-condition, single-image settings, leaving multimodal and multi-image evidence integration under rare-disease data scarcity systematically unevaluated. We introduce MMRareBench, to our knowledge the first rare-disease benchmark jointly evaluating multimodal and multi-image clinical capability across four workflow-aligned tracks: diagnosis, treatment planning, cross-image evidence alignment, and examination suggestion. The benchmark comprises 1,756 question-answer pairs with 7,958 associated medical images curated from PMC case reports, with Orphanet-anchored ontology alignment, track-specific leakage control, evidence-grounded annotations, and a two-level evaluation protocol. A systematic evaluation of 23 MLLMs reveals fragmented capability profiles and universally low treatment-planning performance, with medical-domain models trailing general-purpose MLLMs substantially on multi-image tracks despite competitive diagnostic scores. These patterns are consistent with a capacity dilution effect: medical fine-tuning can narrow the diagnostic gap but may erode the compositional multi-image capability that rare-disease evidence integration demands.
format Preprint
id arxiv_https___arxiv_org_abs_2604_10755
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle MMRareBench: A Rare-Disease Multimodal and Multi-Image Medical Benchmark
Ning, Junzhi
Lin, Jiashi
Fang, Yingying
Li, Wei
Liu, Jiyao
Tang, Cheng
Ma, Chenglong
Tang, Wenhao
Li, Tianbin
Huang, Ziyan
Yang, Guang
He, Junjun
Computer Vision and Pattern Recognition
Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing them to rely strictly on case-level evidence for clinical judgments. Existing benchmarks predominantly evaluate common-condition, single-image settings, leaving multimodal and multi-image evidence integration under rare-disease data scarcity systematically unevaluated. We introduce MMRareBench, to our knowledge the first rare-disease benchmark jointly evaluating multimodal and multi-image clinical capability across four workflow-aligned tracks: diagnosis, treatment planning, cross-image evidence alignment, and examination suggestion. The benchmark comprises 1,756 question-answer pairs with 7,958 associated medical images curated from PMC case reports, with Orphanet-anchored ontology alignment, track-specific leakage control, evidence-grounded annotations, and a two-level evaluation protocol. A systematic evaluation of 23 MLLMs reveals fragmented capability profiles and universally low treatment-planning performance, with medical-domain models trailing general-purpose MLLMs substantially on multi-image tracks despite competitive diagnostic scores. These patterns are consistent with a capacity dilution effect: medical fine-tuning can narrow the diagnostic gap but may erode the compositional multi-image capability that rare-disease evidence integration demands.
title MMRareBench: A Rare-Disease Multimodal and Multi-Image Medical Benchmark
topic Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2604.10755