A Framework for Longitudinal Health AI Agents

Fuente: arXiv
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Autori principali: Lin, Georgianna, Jiang, Rencong, Elhadad, Noémie, Xu, Xuhai "Orson"
Natura: Preprint
Pubblicazione: 2026
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author Lin, Georgianna
Jiang, Rencong
Elhadad, Noémie
Xu, Xuhai "Orson"
author_facet Lin, Georgianna
Jiang, Rencong
Elhadad, Noémie
Xu, Xuhai "Orson"
contents Although artificial intelligence (AI) agents are increasingly proposed to support potentially longitudinal health tasks, such as symptom management, behavior change, and patient support, most current implementations fall short of facilitating user intent and fostering accountability. This contrasts with prior work on supporting longitudinal needs, both within and beyond clinical settings, where follow-up, coherent reasoning, and sustained alignment with individuals' goals are critical for both effectiveness and safety. In this paper, we draw on established clinical and personal health informatics frameworks to define what it would mean to orchestrate longitudinal health interactions with AI agents. We propose a multi-layer framework and corresponding agent architecture that operationalizes adaptation, coherence, continuity, and agency across repeated interactions. Through representative use cases, we demonstrate how longitudinal agents can maintain meaningful engagement, adapt to evolving goals, and support safe, personalized decision-making over time. Our findings underscore both the promise and the complexity of designing systems capable of supporting health trajectories beyond isolated interactions, and we offer guidance for future research and development in multi-session, user-centered health AI.
format Preprint
id arxiv_https___arxiv_org_abs_2604_12019
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle A Framework for Longitudinal Health AI Agents
Lin, Georgianna
Jiang, Rencong
Elhadad, Noémie
Xu, Xuhai "Orson"
Artificial Intelligence
Human-Computer Interaction
Although artificial intelligence (AI) agents are increasingly proposed to support potentially longitudinal health tasks, such as symptom management, behavior change, and patient support, most current implementations fall short of facilitating user intent and fostering accountability. This contrasts with prior work on supporting longitudinal needs, both within and beyond clinical settings, where follow-up, coherent reasoning, and sustained alignment with individuals' goals are critical for both effectiveness and safety. In this paper, we draw on established clinical and personal health informatics frameworks to define what it would mean to orchestrate longitudinal health interactions with AI agents. We propose a multi-layer framework and corresponding agent architecture that operationalizes adaptation, coherence, continuity, and agency across repeated interactions. Through representative use cases, we demonstrate how longitudinal agents can maintain meaningful engagement, adapt to evolving goals, and support safe, personalized decision-making over time. Our findings underscore both the promise and the complexity of designing systems capable of supporting health trajectories beyond isolated interactions, and we offer guidance for future research and development in multi-session, user-centered health AI.
title A Framework for Longitudinal Health AI Agents
topic Artificial Intelligence
Human-Computer Interaction
url https://arxiv.org/abs/2604.12019