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Main Authors: Sannino, Giovanna, De Falco, Ivanoe, Brancati, Nadia, Verde, Laura, Frucci, Maria, Riccio, Daniel, Bevilacqua, Vincenzo, Di Marino, Antonio, Aruta, Lucia, Iuzzolino, Valentina Virginia, Senerchia, Gianmaria, Spisto, Myriam, Dubbioso, Raffaele
Format: Preprint
Published: 2026
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Online Access:https://arxiv.org/abs/2604.16445
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author Sannino, Giovanna
De Falco, Ivanoe
Brancati, Nadia
Verde, Laura
Frucci, Maria
Riccio, Daniel
Bevilacqua, Vincenzo
Di Marino, Antonio
Aruta, Lucia
Iuzzolino, Valentina Virginia
Senerchia, Gianmaria
Spisto, Myriam
Dubbioso, Raffaele
author_facet Sannino, Giovanna
De Falco, Ivanoe
Brancati, Nadia
Verde, Laura
Frucci, Maria
Riccio, Daniel
Bevilacqua, Vincenzo
Di Marino, Antonio
Aruta, Lucia
Iuzzolino, Valentina Virginia
Senerchia, Gianmaria
Spisto, Myriam
Dubbioso, Raffaele
contents Recent advances in Artificial Intelligence (AI) and the exploration of noninvasive, objective biomarkers, such as speech signals, have encouraged the development of algorithms to support the early diagnosis of neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS). Voice changes in subjects suffering from ALS typically manifest as progressive dysarthria, which is a prominent neurodegenerative symptom because it affects patients as the disease progresses. Since voice signals are complex data, the development and use of advanced AI techniques are fundamental to extracting distinctive patterns from them. Validating AI algorithms for ALS diagnosis and monitoring using voice signals is challenging, particularly due to the lack of annotated reference datasets. In this work, we present the outcome of a collaboration between a multidisciplinary team of clinicians and Machine Learning experts to create both a clinically annotated validation dataset and the "Speech Analysis for Neurodegenerative Diseases" (SAND) challenge based on it. Specifically, by analyzing voice disorders, the SAND challenge provides an opportunity to develop, test, and evaluate AI models for the automatic early identification and prediction of ALS disease progression.
format Preprint
id arxiv_https___arxiv_org_abs_2604_16445
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle SAND: The Challenge on Speech Analysis for Neurodegenerative Disease Assessment
Sannino, Giovanna
De Falco, Ivanoe
Brancati, Nadia
Verde, Laura
Frucci, Maria
Riccio, Daniel
Bevilacqua, Vincenzo
Di Marino, Antonio
Aruta, Lucia
Iuzzolino, Valentina Virginia
Senerchia, Gianmaria
Spisto, Myriam
Dubbioso, Raffaele
Audio and Speech Processing
Artificial Intelligence
Computer Vision and Pattern Recognition
Machine Learning
Recent advances in Artificial Intelligence (AI) and the exploration of noninvasive, objective biomarkers, such as speech signals, have encouraged the development of algorithms to support the early diagnosis of neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS). Voice changes in subjects suffering from ALS typically manifest as progressive dysarthria, which is a prominent neurodegenerative symptom because it affects patients as the disease progresses. Since voice signals are complex data, the development and use of advanced AI techniques are fundamental to extracting distinctive patterns from them. Validating AI algorithms for ALS diagnosis and monitoring using voice signals is challenging, particularly due to the lack of annotated reference datasets. In this work, we present the outcome of a collaboration between a multidisciplinary team of clinicians and Machine Learning experts to create both a clinically annotated validation dataset and the "Speech Analysis for Neurodegenerative Diseases" (SAND) challenge based on it. Specifically, by analyzing voice disorders, the SAND challenge provides an opportunity to develop, test, and evaluate AI models for the automatic early identification and prediction of ALS disease progression.
title SAND: The Challenge on Speech Analysis for Neurodegenerative Disease Assessment
topic Audio and Speech Processing
Artificial Intelligence
Computer Vision and Pattern Recognition
Machine Learning
url https://arxiv.org/abs/2604.16445