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| Main Authors: | , , , , , , |
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| Format: | Preprint |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2604.17704 |
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| _version_ | 1866913045930835968 |
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| author | Mohammadi, Mahya Duman, Meryem-Nur Ahmadalidokht, Isa Sadraeian, Mohammad Poulton, Christopher G. Solntsev, Alexander S. Kabakova, Irina V. |
| author_facet | Mohammadi, Mahya Duman, Meryem-Nur Ahmadalidokht, Isa Sadraeian, Mohammad Poulton, Christopher G. Solntsev, Alexander S. Kabakova, Irina V. |
| contents | We investigate quantum spectroscopy with undetected photons for protein detection in the mid-infrared spectral region. Classical Fourier-transform infrared spectroscopy of protein samples (bovine serum albumin and N-terminal pro-brain natriuretic peptide) is used as reference to define the sample's mid-infrared absorption, which is then embedded in a numerical model of a double-pass quantum interferometer. We analyse parameters that influence visibility of the interference pattern formed by the signal beams, including the length of nonlinear crystal, sample length and mirror-sample distance. This leads us to a practical quantum spectrometer design with optimal image contrast at the specific amide I-II spectral bands. The simulated visibility spectra reproduce nearly identically the protein absorption features in the mid-IR and reveal temperature-induced changes to the protein secondary structure. Overall, this provides practical design rules for future quantum bio-spectroscopy applications that use only visible wavelength sources and detectors. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2604_17704 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Quantum Spectroscopy with Undetected Photons for Biomolecular Sensing in the Mid-Infrared Mohammadi, Mahya Duman, Meryem-Nur Ahmadalidokht, Isa Sadraeian, Mohammad Poulton, Christopher G. Solntsev, Alexander S. Kabakova, Irina V. Quantum Physics We investigate quantum spectroscopy with undetected photons for protein detection in the mid-infrared spectral region. Classical Fourier-transform infrared spectroscopy of protein samples (bovine serum albumin and N-terminal pro-brain natriuretic peptide) is used as reference to define the sample's mid-infrared absorption, which is then embedded in a numerical model of a double-pass quantum interferometer. We analyse parameters that influence visibility of the interference pattern formed by the signal beams, including the length of nonlinear crystal, sample length and mirror-sample distance. This leads us to a practical quantum spectrometer design with optimal image contrast at the specific amide I-II spectral bands. The simulated visibility spectra reproduce nearly identically the protein absorption features in the mid-IR and reveal temperature-induced changes to the protein secondary structure. Overall, this provides practical design rules for future quantum bio-spectroscopy applications that use only visible wavelength sources and detectors. |
| title | Quantum Spectroscopy with Undetected Photons for Biomolecular Sensing in the Mid-Infrared |
| topic | Quantum Physics |
| url | https://arxiv.org/abs/2604.17704 |