Noise-Driven Differentiation via Gene Frustration and Epigenetic Fixation
Fuente:
arXiv
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | Preprint |
| Publicado: |
2026
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866917422695448576 |
|---|---|
| author | Plugers, Davey Kaneko, Kunihiko |
| author_facet | Plugers, Davey Kaneko, Kunihiko |
| contents | Gene expression in cells is stochastic, yet differentiation is robust. We propose a mechanism in which frustrated genes with weakly stable intermediate expression undergo noise-driven switching between basins of attraction, followed by irreversible fate fixation through slow epigenetic feedback. Regulatory interactions amplify effective noise and promote differentiation. We derive analytic expression for the logarithmic dependence of differentiation time on noise strength and input-dependent cell-fate selection, and demonstrate homeorhesis, the dynamical robustness of the epigenetic landscape. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2604_18185 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Noise-Driven Differentiation via Gene Frustration and Epigenetic Fixation Plugers, Davey Kaneko, Kunihiko Biological Physics Molecular Networks Gene expression in cells is stochastic, yet differentiation is robust. We propose a mechanism in which frustrated genes with weakly stable intermediate expression undergo noise-driven switching between basins of attraction, followed by irreversible fate fixation through slow epigenetic feedback. Regulatory interactions amplify effective noise and promote differentiation. We derive analytic expression for the logarithmic dependence of differentiation time on noise strength and input-dependent cell-fate selection, and demonstrate homeorhesis, the dynamical robustness of the epigenetic landscape. |
| title | Noise-Driven Differentiation via Gene Frustration and Epigenetic Fixation |
| topic | Biological Physics Molecular Networks |
| url | https://arxiv.org/abs/2604.18185 |