CAHAL: Clinically Applicable resolution enHAncement for Low-resolution MRI scans
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Preprint |
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2026
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| author | Morell-Ortega, Sergio González-Cebrián, Ángela Mansencal, Boris Gadea, Marien Vivo-Hernando, Roberto Rubio, Gregorio Aparici, Fernando de la Iglesia-Vaya, Maria Catheline, Gwenaelle Coupé, Pierrick Manjón, José V. |
| author_facet | Morell-Ortega, Sergio González-Cebrián, Ángela Mansencal, Boris Gadea, Marien Vivo-Hernando, Roberto Rubio, Gregorio Aparici, Fernando de la Iglesia-Vaya, Maria Catheline, Gwenaelle Coupé, Pierrick Manjón, José V. |
| contents | Large-scale automated morphometric analysis of brain MRI is limited by the thick-slice, anisotropic acquisitions prevalent in routine clinical practice. Existing generative super-resolution (SR) methods produce visually compelling isotropic volumes but often introduce anatomical hallucinations, systematic volumetric overestimation, and structural distortions that compromise downstream quantitative analysis and diagnostic safety. To address this, we propose CAHAL (Clinically Applicable resolution enHAncement for Low-resolution MRI scans), a hallucination-robust, physics-informed resolution enhancement framework that operates directly in the patient's native acquisition space. CAHAL employs a deterministic bivariate Mixture of Experts (MoE) architecture routing each input through specialised residual 3D U-Net experts conditioned on both volumetric resolution and acquisition anisotropy, two independent descriptors of clinical MRI acquisition. Experts are optimised with a composite loss combining edge-penalised spatial reconstruction, Fourier-domain spectral coherence matching, and a segmentation-guided semantic consistency constraint. Training pairs are generated on-the-fly via physics-based degradation sampled from a large-scale real-world database, ensuring robust generalisation. Validated on T1-weighted and FLAIR sequences against generative baselines, CAHAL achieves state-of-the-art results, improving the best related methods in terms of accuracy and efficiency. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2604_18781 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | CAHAL: Clinically Applicable resolution enHAncement for Low-resolution MRI scans Morell-Ortega, Sergio González-Cebrián, Ángela Mansencal, Boris Gadea, Marien Vivo-Hernando, Roberto Rubio, Gregorio Aparici, Fernando de la Iglesia-Vaya, Maria Catheline, Gwenaelle Coupé, Pierrick Manjón, José V. Computer Vision and Pattern Recognition Large-scale automated morphometric analysis of brain MRI is limited by the thick-slice, anisotropic acquisitions prevalent in routine clinical practice. Existing generative super-resolution (SR) methods produce visually compelling isotropic volumes but often introduce anatomical hallucinations, systematic volumetric overestimation, and structural distortions that compromise downstream quantitative analysis and diagnostic safety. To address this, we propose CAHAL (Clinically Applicable resolution enHAncement for Low-resolution MRI scans), a hallucination-robust, physics-informed resolution enhancement framework that operates directly in the patient's native acquisition space. CAHAL employs a deterministic bivariate Mixture of Experts (MoE) architecture routing each input through specialised residual 3D U-Net experts conditioned on both volumetric resolution and acquisition anisotropy, two independent descriptors of clinical MRI acquisition. Experts are optimised with a composite loss combining edge-penalised spatial reconstruction, Fourier-domain spectral coherence matching, and a segmentation-guided semantic consistency constraint. Training pairs are generated on-the-fly via physics-based degradation sampled from a large-scale real-world database, ensuring robust generalisation. Validated on T1-weighted and FLAIR sequences against generative baselines, CAHAL achieves state-of-the-art results, improving the best related methods in terms of accuracy and efficiency. |
| title | CAHAL: Clinically Applicable resolution enHAncement for Low-resolution MRI scans |
| topic | Computer Vision and Pattern Recognition |
| url | https://arxiv.org/abs/2604.18781 |