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| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2026
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| Materias: | |
| Acceso en línea: | https://arxiv.org/abs/2604.23945 |
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| _version_ | 1866915960575754240 |
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| author | Luo, Tenglong Guo, Yiqing Su, Shanshan Yang, Qiaoyu Deng, Wen Huang, Zhangfeng Yu, Zhiquan Yu, Dawen Ke, Yubin Yang, Hua Wang, Jiecong Zhang, Dewen Wu, Yuanhao |
| author_facet | Luo, Tenglong Guo, Yiqing Su, Shanshan Yang, Qiaoyu Deng, Wen Huang, Zhangfeng Yu, Zhiquan Yu, Dawen Ke, Yubin Yang, Hua Wang, Jiecong Zhang, Dewen Wu, Yuanhao |
| contents | Long-term stability of neural interfaces is frequently compromised by mechanical mismatch and chronic neuroinflammation, often leading to electrode detachment and signal failure. While hydrogel coatings offer a solution, conventional designs typically rely on exogenous conductive fillers that can sacrifice mechanical flexibility or induce toxicity. Here, we report on a soft neural interface based on the supramolecular co-assembly of a renewable natural polysaccharide, okra mucilage polysaccharide (OMP), and an α-helical peptide amphiphiles (APA). The resulting OMP-APA hydrogel (OP gel) exhibits environment-responsive enhancements in bioadhesion and charge-transport capability triggered by physiological pH and electrical stimulation. These properties arise from intrinsic, stimulus-responsive alterations in fibre architecture and orientation, eliminating the need for conductive fillers. Leveraging interfacial liquid-liquid phase separation, we demonstrate the in situ coating of ultra-thin OP-gel coating onto carbon fibre electrodes (CFE). The OP-gel-coated electrodes (OP-CFE) significantly mitigate foreign body responses and glial scarring, enabling stable, high-quality neural recordings in a mouse cortical in vivo model. Our findings provide a versatile strategy for constructing seamless, multifunctional bio-interfaces through supramolecular co-assembly, with broad implications for advancing neural prosthetics and neuroscience research. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2604_23945 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | An in situ self-adaptive hydrogel coating enables seamless neural interfaces via okra mucilage polysaccharide and α-helical peptide amphiphiles co-assembly Luo, Tenglong Guo, Yiqing Su, Shanshan Yang, Qiaoyu Deng, Wen Huang, Zhangfeng Yu, Zhiquan Yu, Dawen Ke, Yubin Yang, Hua Wang, Jiecong Zhang, Dewen Wu, Yuanhao Biological Physics Long-term stability of neural interfaces is frequently compromised by mechanical mismatch and chronic neuroinflammation, often leading to electrode detachment and signal failure. While hydrogel coatings offer a solution, conventional designs typically rely on exogenous conductive fillers that can sacrifice mechanical flexibility or induce toxicity. Here, we report on a soft neural interface based on the supramolecular co-assembly of a renewable natural polysaccharide, okra mucilage polysaccharide (OMP), and an α-helical peptide amphiphiles (APA). The resulting OMP-APA hydrogel (OP gel) exhibits environment-responsive enhancements in bioadhesion and charge-transport capability triggered by physiological pH and electrical stimulation. These properties arise from intrinsic, stimulus-responsive alterations in fibre architecture and orientation, eliminating the need for conductive fillers. Leveraging interfacial liquid-liquid phase separation, we demonstrate the in situ coating of ultra-thin OP-gel coating onto carbon fibre electrodes (CFE). The OP-gel-coated electrodes (OP-CFE) significantly mitigate foreign body responses and glial scarring, enabling stable, high-quality neural recordings in a mouse cortical in vivo model. Our findings provide a versatile strategy for constructing seamless, multifunctional bio-interfaces through supramolecular co-assembly, with broad implications for advancing neural prosthetics and neuroscience research. |
| title | An in situ self-adaptive hydrogel coating enables seamless neural interfaces via okra mucilage polysaccharide and α-helical peptide amphiphiles co-assembly |
| topic | Biological Physics |
| url | https://arxiv.org/abs/2604.23945 |