DepthPilot: From Controllability to Interpretability in Colonoscopy Video Generation

Fuente: arXiv
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Autores principales: Fu, Junhu, Chen, Ke, Guo, Weidong, Liang, Shuyu, Xu, Jie, Ma, Chen, Wang, Kehao, Lin, Shengli, Li, Zeju, Wang, Yuanyuan, Guo, Yi, Li, Shuo
Formato: Preprint
Publicado: 2026
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author Fu, Junhu
Chen, Ke
Guo, Weidong
Liang, Shuyu
Xu, Jie
Ma, Chen
Wang, Kehao
Lin, Shengli
Li, Zeju
Wang, Yuanyuan
Guo, Yi
Li, Shuo
author_facet Fu, Junhu
Chen, Ke
Guo, Weidong
Liang, Shuyu
Xu, Jie
Ma, Chen
Wang, Kehao
Lin, Shengli
Li, Zeju
Wang, Yuanyuan
Guo, Yi
Li, Shuo
contents Controllable medical video generation has achieved remarkable progress, but it still lacks interpretability, which requires the alignment of generated contents with physical priors and faithful clinical manifestations. To push the boundaries from mere controllability to interpretability, we propose DepthPilot, the first interpretable framework for colonoscopy video generation. This work takes a step toward trustworthy generation through two synergistic paradigms. To achieve explicit geometric grounding, DepthPilot devises a prior distribution alignment strategy, injecting depth constraints into the diffusion backbone via parameter-efficient fine-tuning to ensure anatomical fidelity. To enhance intrinsic nonlinear modeling under these geometric constraints, DepthPilot employs an adaptive spline denoising module, replacing fixed linear weights with learnable spline functions to capture complex spatio-temporal dynamics. Extensive evaluations across three public datasets and in-house clinical data confirm DepthPilot's robust ability to produce physically consistent videos. It achieves FID scores below 15 across all benchmarks and ranks first in clinician assessments, bridging the gap between "visually realistic" and "clinically interpretable". Moreover, DepthPilot-generated videos are expected to enable reliable 3D reconstruction, facilitating surgical navigation and blind region identification, and serve as a foundation toward the colorectal world model.
format Preprint
id arxiv_https___arxiv_org_abs_2604_26232
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle DepthPilot: From Controllability to Interpretability in Colonoscopy Video Generation
Fu, Junhu
Chen, Ke
Guo, Weidong
Liang, Shuyu
Xu, Jie
Ma, Chen
Wang, Kehao
Lin, Shengli
Li, Zeju
Wang, Yuanyuan
Guo, Yi
Li, Shuo
Computer Vision and Pattern Recognition
Artificial Intelligence
Controllable medical video generation has achieved remarkable progress, but it still lacks interpretability, which requires the alignment of generated contents with physical priors and faithful clinical manifestations. To push the boundaries from mere controllability to interpretability, we propose DepthPilot, the first interpretable framework for colonoscopy video generation. This work takes a step toward trustworthy generation through two synergistic paradigms. To achieve explicit geometric grounding, DepthPilot devises a prior distribution alignment strategy, injecting depth constraints into the diffusion backbone via parameter-efficient fine-tuning to ensure anatomical fidelity. To enhance intrinsic nonlinear modeling under these geometric constraints, DepthPilot employs an adaptive spline denoising module, replacing fixed linear weights with learnable spline functions to capture complex spatio-temporal dynamics. Extensive evaluations across three public datasets and in-house clinical data confirm DepthPilot's robust ability to produce physically consistent videos. It achieves FID scores below 15 across all benchmarks and ranks first in clinician assessments, bridging the gap between "visually realistic" and "clinically interpretable". Moreover, DepthPilot-generated videos are expected to enable reliable 3D reconstruction, facilitating surgical navigation and blind region identification, and serve as a foundation toward the colorectal world model.
title DepthPilot: From Controllability to Interpretability in Colonoscopy Video Generation
topic Computer Vision and Pattern Recognition
Artificial Intelligence
url https://arxiv.org/abs/2604.26232