Trust Me, I'm a Doctor?
Fuente:
arXiv
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| Autores principales: | , |
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| Formato: | Preprint |
| Publicado: |
2026
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| Materias: | |
| Acceso en línea: | |
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| _version_ | 1866918529377239040 |
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| author | Shahn, Zach Stensrud, Mats |
| author_facet | Shahn, Zach Stensrud, Mats |
| contents | Clinical trials usually target average treatment effects, but treatment decisions are made for individuals. This tension motivates a common criticism of evidence-based medicine: a treatment that is beneficial on average may be inappropriate for a particular patient, and skilled physicians may outperform rigid adherence to the strategy that performed best in a randomized trial. We consider how randomized and observational data from the same target population can be used to assess that possibility. Specifically, we study settings in which a randomized trial is nested within an observational cohort, so that outcomes are observed under treatment, control, and usual care. We ask what the observed data can reveal about how often physicians outperform the strategy suggested by the trial. We derive sharp bounds on the proportion of physicians whose personal strategies perform better than always choosing the better performing treatment from the trial under the assumption that no physician's strategy is worse than always choosing the worse performing treatment from the trial. These results shed light on when clinical data support relying on physician discretion over the trial-average recommendation and when stronger justification is required. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2605_01050 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Trust Me, I'm a Doctor? Shahn, Zach Stensrud, Mats Applications Clinical trials usually target average treatment effects, but treatment decisions are made for individuals. This tension motivates a common criticism of evidence-based medicine: a treatment that is beneficial on average may be inappropriate for a particular patient, and skilled physicians may outperform rigid adherence to the strategy that performed best in a randomized trial. We consider how randomized and observational data from the same target population can be used to assess that possibility. Specifically, we study settings in which a randomized trial is nested within an observational cohort, so that outcomes are observed under treatment, control, and usual care. We ask what the observed data can reveal about how often physicians outperform the strategy suggested by the trial. We derive sharp bounds on the proportion of physicians whose personal strategies perform better than always choosing the better performing treatment from the trial under the assumption that no physician's strategy is worse than always choosing the worse performing treatment from the trial. These results shed light on when clinical data support relying on physician discretion over the trial-average recommendation and when stronger justification is required. |
| title | Trust Me, I'm a Doctor? |
| topic | Applications |
| url | https://arxiv.org/abs/2605.01050 |