Deep Speckle Holography Redefines Label-free Nanoparticle Phenotyping
Fuente:
arXiv
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Format: | Preprint |
| Veröffentlicht: |
2026
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1866914527415631872 |
|---|---|
| author | Zhu, Yanmin Li, Yuxing Chen, Jingyan Ho, Derek Yuen-Wa Wang, Chutian Zhang, Yuzhe Wang, Xue-Qi Lu, Bo Fang, James Kar-Hei Ling, Francis Chi Chung Tadesse, Loza F. Lam, Edmund Y. |
| author_facet | Zhu, Yanmin Li, Yuxing Chen, Jingyan Ho, Derek Yuen-Wa Wang, Chutian Zhang, Yuzhe Wang, Xue-Qi Lu, Bo Fang, James Kar-Hei Ling, Francis Chi Chung Tadesse, Loza F. Lam, Edmund Y. |
| contents | Nanoparticle metrology has long been constrained by the assumption that, in mixed and unprocessed fluids, particle size, morphology, composition, and species-specific abundance cannot be resolved simultaneously from a single label-free measurement. Here, we revisit this long-standing limitation by showing that complex forward speckle-holographic fields define an information-rich optical space for multidimensional particle signatures. We report deep speckle holography, a physics-informed generative framework that profiles particle identity, size, morphology, and species-resolved abundance from a single non-contact optical measurement. Across purified suspensions, mixed particle populations, environmental waters, human urine, and other unprocessed native fluids, the method enables direct nanoparticle inference without purification, labeling, or destructive preprocessing, delivering concurrent multidimensional readouts in 0.9 s over a dynamic range spanning 10 orders of magnitude. Deep speckle holography establishes a route toward direct label-free nanoparticle phenotyping in real-world fluids, moving nanoscale measurement beyond isolated-particle characterization toward multidimensional inference in complex mixtures, and expanding the scope of questions nanoscale measurement can address, from real-time tracking of nanoparticle transformations in living and environmental systems to non-invasive quality control of nanomedicine formulations, and beyond. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2605_01982 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Deep Speckle Holography Redefines Label-free Nanoparticle Phenotyping Zhu, Yanmin Li, Yuxing Chen, Jingyan Ho, Derek Yuen-Wa Wang, Chutian Zhang, Yuzhe Wang, Xue-Qi Lu, Bo Fang, James Kar-Hei Ling, Francis Chi Chung Tadesse, Loza F. Lam, Edmund Y. Image and Video Processing Nanoparticle metrology has long been constrained by the assumption that, in mixed and unprocessed fluids, particle size, morphology, composition, and species-specific abundance cannot be resolved simultaneously from a single label-free measurement. Here, we revisit this long-standing limitation by showing that complex forward speckle-holographic fields define an information-rich optical space for multidimensional particle signatures. We report deep speckle holography, a physics-informed generative framework that profiles particle identity, size, morphology, and species-resolved abundance from a single non-contact optical measurement. Across purified suspensions, mixed particle populations, environmental waters, human urine, and other unprocessed native fluids, the method enables direct nanoparticle inference without purification, labeling, or destructive preprocessing, delivering concurrent multidimensional readouts in 0.9 s over a dynamic range spanning 10 orders of magnitude. Deep speckle holography establishes a route toward direct label-free nanoparticle phenotyping in real-world fluids, moving nanoscale measurement beyond isolated-particle characterization toward multidimensional inference in complex mixtures, and expanding the scope of questions nanoscale measurement can address, from real-time tracking of nanoparticle transformations in living and environmental systems to non-invasive quality control of nanomedicine formulations, and beyond. |
| title | Deep Speckle Holography Redefines Label-free Nanoparticle Phenotyping |
| topic | Image and Video Processing |
| url | https://arxiv.org/abs/2605.01982 |