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author Lems, Carlijn
Moonemans, Sander
Klubíčková, Natálie
Brattoli, Biagio
Lee, Taebum
Kim, Seokhwi
Vilaplana, Veronica
Pons, Laura
Hochman, Sapir
Suárez-Franck, Mauricio Eduardo
Fernandez, Pedro Luis
Drachneris, Julius
Petroska, Donatas
Augulis, Renaldas
Laurinavicius, Arvydas
Oliveira, Domingos
Montezuma, Diana
Bouwmeester, Anouk B.
van Midden, Dominique
Vos, Anne-Marie
Vos, Shoko
van Ipenburg, Jolique
Balkenhol, Maschenka
Winkler, Koen
Nagtegaal, Iris
Hebeda, Konnie
Flucke, Uta
Grünberg, Katrien
Skopal, Josef
Chohan, Brinder S.
Temprana-Salvador, Jordi
Munari, Enrico
Cima, Luca
Querzoli, Giulia
Belisario, Yosamin Gonzalez
Faber, Jaeike W.
van Leenders, Geert J. L. H.
von der Thüsen, Jan H.
Brosens, Lodewijk A. A.
de Krijger, Ronald R.
Wesseling, Pieter
Florquin, Sandrine
Maniewski, Mateusz
Kowalewski, Adam
Barna, Robert
Tiniakos, Dina
Gros, Joan Lop
Donders, Rogier
Maurits, Jake S. F.
Lu, Ming Yang
Chen, Chengkuan
Mahmood, Faisal
van der Laak, Jeroen
Khalili, Nadieh
Meeuwsen, Frédérique
Ciompi, Francesco
author_facet Lems, Carlijn
Moonemans, Sander
Klubíčková, Natálie
Brattoli, Biagio
Lee, Taebum
Kim, Seokhwi
Vilaplana, Veronica
Pons, Laura
Hochman, Sapir
Suárez-Franck, Mauricio Eduardo
Fernandez, Pedro Luis
Drachneris, Julius
Petroska, Donatas
Augulis, Renaldas
Laurinavicius, Arvydas
Oliveira, Domingos
Montezuma, Diana
Bouwmeester, Anouk B.
van Midden, Dominique
Vos, Anne-Marie
Vos, Shoko
van Ipenburg, Jolique
Balkenhol, Maschenka
Winkler, Koen
Nagtegaal, Iris
Hebeda, Konnie
Flucke, Uta
Grünberg, Katrien
Skopal, Josef
Chohan, Brinder S.
Temprana-Salvador, Jordi
Munari, Enrico
Cima, Luca
Querzoli, Giulia
Belisario, Yosamin Gonzalez
Faber, Jaeike W.
van Leenders, Geert J. L. H.
von der Thüsen, Jan H.
Brosens, Lodewijk A. A.
de Krijger, Ronald R.
Wesseling, Pieter
Florquin, Sandrine
Maniewski, Mateusz
Kowalewski, Adam
Barna, Robert
Tiniakos, Dina
Gros, Joan Lop
Donders, Rogier
Maurits, Jake S. F.
Lu, Ming Yang
Chen, Chengkuan
Mahmood, Faisal
van der Laak, Jeroen
Khalili, Nadieh
Meeuwsen, Frédérique
Ciompi, Francesco
contents Foundation models with visual question answering capabilities for digital pathology are emerging. Such unprecedented technology requires independent benchmarking to assess its potential in assisting pathologists in routine diagnostics. We created DALPHIN, the first multicentric open benchmark for pathology AI copilots, comprising 1236 images from 300 cases, spanning 130 rare to common diagnoses, 6 countries, and 14 subspecialties. The DALPHIN design and dataset are introduced alongside a human performance benchmark of 31 pathologists from 10 countries with varying expertise. We report results for two general-purpose (GPT-5, Gemini 2.5 Pro) and one pathology-specific copilot (PathChat+) for sequential and independent answer generation. We observed no statistically significant difference from expert-level performance in four of six tasks for PathChat, 2/6 tasks for Gemini, and 1/6 tasks for GPT. DALPHIN is publicly released with sequestered, indirectly accessible ground truth to foster robust and enduring benchmarking. Data, methods, and the evaluation platform are accessible through dalphin.grand-challenge.org.
format Preprint
id arxiv_https___arxiv_org_abs_2605_03544
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle DALPHIN: Benchmarking Digital Pathology AI Copilots Against Pathologists on an Open Multicentric Dataset
Lems, Carlijn
Moonemans, Sander
Klubíčková, Natálie
Brattoli, Biagio
Lee, Taebum
Kim, Seokhwi
Vilaplana, Veronica
Pons, Laura
Hochman, Sapir
Suárez-Franck, Mauricio Eduardo
Fernandez, Pedro Luis
Drachneris, Julius
Petroska, Donatas
Augulis, Renaldas
Laurinavicius, Arvydas
Oliveira, Domingos
Montezuma, Diana
Bouwmeester, Anouk B.
van Midden, Dominique
Vos, Anne-Marie
Vos, Shoko
van Ipenburg, Jolique
Balkenhol, Maschenka
Winkler, Koen
Nagtegaal, Iris
Hebeda, Konnie
Flucke, Uta
Grünberg, Katrien
Skopal, Josef
Chohan, Brinder S.
Temprana-Salvador, Jordi
Munari, Enrico
Cima, Luca
Querzoli, Giulia
Belisario, Yosamin Gonzalez
Faber, Jaeike W.
van Leenders, Geert J. L. H.
von der Thüsen, Jan H.
Brosens, Lodewijk A. A.
de Krijger, Ronald R.
Wesseling, Pieter
Florquin, Sandrine
Maniewski, Mateusz
Kowalewski, Adam
Barna, Robert
Tiniakos, Dina
Gros, Joan Lop
Donders, Rogier
Maurits, Jake S. F.
Lu, Ming Yang
Chen, Chengkuan
Mahmood, Faisal
van der Laak, Jeroen
Khalili, Nadieh
Meeuwsen, Frédérique
Ciompi, Francesco
Computer Vision and Pattern Recognition
Artificial Intelligence
Foundation models with visual question answering capabilities for digital pathology are emerging. Such unprecedented technology requires independent benchmarking to assess its potential in assisting pathologists in routine diagnostics. We created DALPHIN, the first multicentric open benchmark for pathology AI copilots, comprising 1236 images from 300 cases, spanning 130 rare to common diagnoses, 6 countries, and 14 subspecialties. The DALPHIN design and dataset are introduced alongside a human performance benchmark of 31 pathologists from 10 countries with varying expertise. We report results for two general-purpose (GPT-5, Gemini 2.5 Pro) and one pathology-specific copilot (PathChat+) for sequential and independent answer generation. We observed no statistically significant difference from expert-level performance in four of six tasks for PathChat, 2/6 tasks for Gemini, and 1/6 tasks for GPT. DALPHIN is publicly released with sequestered, indirectly accessible ground truth to foster robust and enduring benchmarking. Data, methods, and the evaluation platform are accessible through dalphin.grand-challenge.org.
title DALPHIN: Benchmarking Digital Pathology AI Copilots Against Pathologists on an Open Multicentric Dataset
topic Computer Vision and Pattern Recognition
Artificial Intelligence
url https://arxiv.org/abs/2605.03544