Sparse Autoencoder Decomposition of Clinical Sequence Model Representations: Feature Complexity, Task Specialisation, and Mortality Prediction
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| Format: | Preprint |
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2026
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| _version_ | 1866913091786113024 |
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| author | Sainsbury, Chris Dong, Feng Karwath, Andreas |
| author_facet | Sainsbury, Chris Dong, Feng Karwath, Andreas |
| contents | Sparse autoencoders (SAEs) have been applied to large language models and protein language models, but not systematically to electronic health record (EHR) foundation models. We train TopK SAEs on FlatASCEND, a 14.5-million-parameter autoregressive clinical sequence model, at all 10 residual stream extraction points on INSPECT (outpatient) and MIMIC-IV (ICU). SAE decomposition reveals progressive abstraction across transformer depth: layer-0 features are near-perfect token detectors (45.7% singleton), while layer-6 features span approximately 30 token types across multiple clinical categories (0.5% singleton). Under full-sequence simple linear probes, SAE features outperform dense representations for discrete event prediction (mortality) while dense representations outperform for continuous magnitude prediction (length of stay) - a probe-level representational phenomenon that does not extend to clinically relevant leakage-safe windows, where dense representations match or exceed SAE features across all tested settings (eICU-CRD 48-hour AUC: SAE 0.871 versus dense 0.880; base model zero-shot, SAE dictionaries trained on eICU activations; MIMIC-IV: 0.836 versus 0.914; INSPECT 1-year/3-year: 0.697 versus 0.800). A delta-mode intervention method reduces SAE perturbation noise by 86x, enabling cleaner feature-level experiments, though the resulting perturbation effects are larger than random controls in 3 of 4 conditions but not formally significant. Feature reproducibility across random seeds is 21%, and individual features should be interpreted as illustrative rather than stable. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2605_04072 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Sparse Autoencoder Decomposition of Clinical Sequence Model Representations: Feature Complexity, Task Specialisation, and Mortality Prediction Sainsbury, Chris Dong, Feng Karwath, Andreas Machine Learning Artificial Intelligence Computation and Language Sparse autoencoders (SAEs) have been applied to large language models and protein language models, but not systematically to electronic health record (EHR) foundation models. We train TopK SAEs on FlatASCEND, a 14.5-million-parameter autoregressive clinical sequence model, at all 10 residual stream extraction points on INSPECT (outpatient) and MIMIC-IV (ICU). SAE decomposition reveals progressive abstraction across transformer depth: layer-0 features are near-perfect token detectors (45.7% singleton), while layer-6 features span approximately 30 token types across multiple clinical categories (0.5% singleton). Under full-sequence simple linear probes, SAE features outperform dense representations for discrete event prediction (mortality) while dense representations outperform for continuous magnitude prediction (length of stay) - a probe-level representational phenomenon that does not extend to clinically relevant leakage-safe windows, where dense representations match or exceed SAE features across all tested settings (eICU-CRD 48-hour AUC: SAE 0.871 versus dense 0.880; base model zero-shot, SAE dictionaries trained on eICU activations; MIMIC-IV: 0.836 versus 0.914; INSPECT 1-year/3-year: 0.697 versus 0.800). A delta-mode intervention method reduces SAE perturbation noise by 86x, enabling cleaner feature-level experiments, though the resulting perturbation effects are larger than random controls in 3 of 4 conditions but not formally significant. Feature reproducibility across random seeds is 21%, and individual features should be interpreted as illustrative rather than stable. |
| title | Sparse Autoencoder Decomposition of Clinical Sequence Model Representations: Feature Complexity, Task Specialisation, and Mortality Prediction |
| topic | Machine Learning Artificial Intelligence Computation and Language |
| url | https://arxiv.org/abs/2605.04072 |