BOIN Designs for Dose Escalation With Selected Dose Combinations in Oncology Phase I Trials
Fuente:
arXiv
Saved in:
| Main Authors: | Chen, Yuxuan, Zhou, Haiming, Nakajima, Keiko, He, Philip |
|---|---|
| Format: | Preprint |
| Published: |
2026
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
Precision Dose-Finding Design for Phase I Oncology Trials by Integrating Pharmacology Data
by: Lee, Kyong Ju, et al.
Published: (2025)
by: Lee, Kyong Ju, et al.
Published: (2025)
Defining Utility as a Measure of Preference Under Uncertainty in Phase I-II Oncology Dose Finding Trials
by: Hall, Andrew, et al.
Published: (2025)
by: Hall, Andrew, et al.
Published: (2025)
A Seamless Phase II/III Design with Dose Optimization for Oncology Drug Development
by: Li, Yuhan, et al.
Published: (2024)
by: Li, Yuhan, et al.
Published: (2024)
CUI-MET: Clinical Utility Index Dose Optimization Approach for Multiple-Dose, Multiple-Outcome Randomized Trial Designs
by: Zhang, Fanni, et al.
Published: (2025)
by: Zhang, Fanni, et al.
Published: (2025)
Hybrid Non-informative and Informative Prior Model-assisted Designs for Mid-trial Dose Insertion
by: Yamada, Kana, et al.
Published: (2026)
by: Yamada, Kana, et al.
Published: (2026)
Adaptive Weighting for Time-to-Event Continual Reassessment Method: Improving Safety in Phase I Dose-Finding Through Data-Driven Delay Distribution Estimation
by: Amevor, Robert, et al.
Published: (2026)
by: Amevor, Robert, et al.
Published: (2026)
A Bayesian Treatment Selection Design for Phase II Randomised Cancer Clinical Trials
by: Komaki, Moka, et al.
Published: (2025)
by: Komaki, Moka, et al.
Published: (2025)
BE-BOIN: A Dose Optimization Design Accommodating Backfill and Late-Onset Toxicity
by: Chen, Kai, et al.
Published: (2025)
by: Chen, Kai, et al.
Published: (2025)
Feasible Dose-Response Curves for Continuous Treatments Under Positivity Violations
by: Bao, Han, et al.
Published: (2025)
by: Bao, Han, et al.
Published: (2025)
Dose optimization design accounting for unknown patient heterogeneity in cancer clinical trials
by: Silva, Rebecca B., et al.
Published: (2025)
by: Silva, Rebecca B., et al.
Published: (2025)
Evaluating Bias Reduction Methods in Binary Emax Model for Reliable Dose-Response Estimation
by: Zhang, Jiangshan, et al.
Published: (2025)
by: Zhang, Jiangshan, et al.
Published: (2025)
HAL-Based Plug-in Estimation with Pointwise Asymptotic Normality of the Causal Dose-Response Curve
by: Shi, Junming, et al.
Published: (2024)
by: Shi, Junming, et al.
Published: (2024)
DEMO: Dose Exploration, Monitoring, and Optimization Using a Biological Mediator for Clinical Outcomes
by: Yang, Cheng-Han, et al.
Published: (2024)
by: Yang, Cheng-Han, et al.
Published: (2024)
MUCE: Bayesian Hierarchical Modeling for the Design and Analysis of Phase 1b Multiple Expansion Cohort Trials
by: Lyu, Jiaying, et al.
Published: (2020)
by: Lyu, Jiaying, et al.
Published: (2020)
Robust Emax Model Fitting: Addressing Nonignorable Missing Binary Outcome in Dose-Response Analysis
by: Zhang, Jiangshan, et al.
Published: (2024)
by: Zhang, Jiangshan, et al.
Published: (2024)
Semiparametric Piecewise Accelerated Failure Time Model for the Analysis of Immune-Oncology Clinical Trials
by: Sunami, Hisato, et al.
Published: (2024)
by: Sunami, Hisato, et al.
Published: (2024)
The Modified Combo i3+3 Design for Novel-Novel Combination Dose-Finding Trials in Oncology
by: Liu, Jiaxin, et al.
Published: (2024)
by: Liu, Jiaxin, et al.
Published: (2024)
The Backfill i3+3 Design for Dose-Finding Trials in Oncology
by: Liu, Jiaxin, et al.
Published: (2023)
by: Liu, Jiaxin, et al.
Published: (2023)
A Utility Score Framework for Dose Optimization Studies with Binary Efficacy-Safety Endpoints: Sample Size Determination and Bias Characterization
by: Gu, Xuemin, et al.
Published: (2026)
by: Gu, Xuemin, et al.
Published: (2026)
BMW: Bayesian Model-Assisted Adaptive Phase II Clinical Trial Design for Win Ratio Statistic
by: Zhu, Di, et al.
Published: (2026)
by: Zhu, Di, et al.
Published: (2026)
Distribution-Free Selection of Low-Risk Oncology Patients for Survival Beyond a Time Horizon
by: Sesia, Matteo, et al.
Published: (2025)
by: Sesia, Matteo, et al.
Published: (2025)
Optimal sequential two-stage Bayes Factor Design for two-arm clinical Phase II Trials with binary Endpoints
by: Kelter, Riko
Published: (2026)
by: Kelter, Riko
Published: (2026)
Estimands for Early Phase Dose Optimization Trials in Oncology
by: Mukherjee, Ayon, et al.
Published: (2025)
by: Mukherjee, Ayon, et al.
Published: (2025)
Bayesian Design and Analysis of Precision Trials with Partial Borrowing
by: Golchi, Shirin, et al.
Published: (2026)
by: Golchi, Shirin, et al.
Published: (2026)
Two-stage Adaptive Design Cluster Randomised Trials
by: Watson, Samuel I., et al.
Published: (2026)
by: Watson, Samuel I., et al.
Published: (2026)
A Bayesian Hybrid Design with Borrowing from Historical Study
by: Lu, Zhaohua, et al.
Published: (2024)
by: Lu, Zhaohua, et al.
Published: (2024)
On Assessing Overall Survival (OS) in Oncology Studies
by: Hsu, Jason C.
Published: (2025)
by: Hsu, Jason C.
Published: (2025)
Adjusting for Selection Bias Due to Missing Eligibility Criteria in Emulated Target Trials
by: Benz, Luke, et al.
Published: (2024)
by: Benz, Luke, et al.
Published: (2024)
Simulation-Guided Planning of a Target Trial Emulated Cluster Randomized Trial for Mass Small-Quantity Lipid Nutrient Supplementation Combined with Expanded Program on Immunization in Rural Niger
by: Alam, Shomoita, et al.
Published: (2025)
by: Alam, Shomoita, et al.
Published: (2025)
Mixture of Finite Mixtures Model for Basket Trial
by: Geng, Junxian, et al.
Published: (2020)
by: Geng, Junxian, et al.
Published: (2020)
An Estimator-Robust Design for Augmenting Randomized Controlled Trial with External Real-World Data
by: Qiu, Sky, et al.
Published: (2025)
by: Qiu, Sky, et al.
Published: (2025)
Power and Sample Size Calculations for Bayes Factors in two-arm clinical Phase II Trials with binary Endpoints
by: Kelter, Riko
Published: (2026)
by: Kelter, Riko
Published: (2026)
Cumulative Logit Ordinal Regression with Proportional Odds under Nonignorable Missing Response -- Application to Phase III Trial
by: Maity, Arnab Kumar, et al.
Published: (2025)
by: Maity, Arnab Kumar, et al.
Published: (2025)
A Bayesian Discrete Framework for Enhancing Decision-Making Processes in Clinical Trial Designs and Evaluations
by: Pramanik, Paramahansa, et al.
Published: (2026)
by: Pramanik, Paramahansa, et al.
Published: (2026)
An Adaptive Phase II Trial Design for Dose Selection and Addition in Microfilarial Infections
by: Zehetmayer, Sonja, et al.
Published: (2026)
by: Zehetmayer, Sonja, et al.
Published: (2026)
Evaluating causal effects on time-to-event outcomes in an RCT in Oncology with treatment discontinuation
by: Ballerini, Veronica, et al.
Published: (2023)
by: Ballerini, Veronica, et al.
Published: (2023)
Implementing Response-Adaptive Randomisation in Stratified Rare-disease Trials: Design Challenges and Practical Solutions
by: Das, Rajenki, et al.
Published: (2024)
by: Das, Rajenki, et al.
Published: (2024)
Designing Efficient Hybrid and Single-Arm Trials: External Control Borrowing and Sample Size Calculation
by: Gao, Yujing, et al.
Published: (2025)
by: Gao, Yujing, et al.
Published: (2025)
Truncated Cauchy Combination Test: a Robust and Powerful P-value Combination Method with Arbitrary Correlations
by: Chen, Bo, et al.
Published: (2025)
by: Chen, Bo, et al.
Published: (2025)
Nonparametric Bayesian Multi-Treatment Mixture Cure Survival Model with Application in Pediatric Oncology
by: Chang, Peter, et al.
Published: (2025)
by: Chang, Peter, et al.
Published: (2025)
Similar Items
-
Precision Dose-Finding Design for Phase I Oncology Trials by Integrating Pharmacology Data
by: Lee, Kyong Ju, et al.
Published: (2025) -
Defining Utility as a Measure of Preference Under Uncertainty in Phase I-II Oncology Dose Finding Trials
by: Hall, Andrew, et al.
Published: (2025) -
A Seamless Phase II/III Design with Dose Optimization for Oncology Drug Development
by: Li, Yuhan, et al.
Published: (2024) -
CUI-MET: Clinical Utility Index Dose Optimization Approach for Multiple-Dose, Multiple-Outcome Randomized Trial Designs
by: Zhang, Fanni, et al.
Published: (2025) -
Hybrid Non-informative and Informative Prior Model-assisted Designs for Mid-trial Dose Insertion
by: Yamada, Kana, et al.
Published: (2026)