Programmable spatial coherence tomography: diffraction-limited three-dimensional reflection imaging under modulated monochromatic illumination
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arXiv
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2026
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| _version_ | 1866915987262013440 |
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| author | Hugonnet, Herve Choi, Jieun Kim, Gyoung Hwan Oh, Chulmin Cho, Jimin Lee, Chungha Shin, Su-Jin Park, Sujin Koo, Bon-Kyoung Oh, Wang-Yuhl Kim, Pilhan Park, YongKeun |
| author_facet | Hugonnet, Herve Choi, Jieun Kim, Gyoung Hwan Oh, Chulmin Cho, Jimin Lee, Chungha Shin, Su-Jin Park, Sujin Koo, Bon-Kyoung Oh, Wang-Yuhl Kim, Pilhan Park, YongKeun |
| contents | Depth sectioning in reflection microscopy has predominantly relied on temporal coherence gating. Here we show that volumetric reflection tomography at diffraction-limited resolution can be achieved under monochromatic illumination by engineering spatial, rather than temporal, coherence. In programmable spatial coherence tomography (PSCT), a sequence of pupil-coded illumination patterns with angular-spectrum diversity generates measurement redundancy enabling the system to calibrate itself, jointly retrieving aberrations, illumination profiles, and sample motion without guide stars or modal priors. We demonstrate label-free volumetric imaging of thick human tissues, organoids, frequency-resolved dynamic contrast, and high-resolution in vivo brain imaging through a cranial window. These results position PSCT as an alternative to temporal coherence based reflection imaging in complex biological systems. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2605_05747 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Programmable spatial coherence tomography: diffraction-limited three-dimensional reflection imaging under modulated monochromatic illumination Hugonnet, Herve Choi, Jieun Kim, Gyoung Hwan Oh, Chulmin Cho, Jimin Lee, Chungha Shin, Su-Jin Park, Sujin Koo, Bon-Kyoung Oh, Wang-Yuhl Kim, Pilhan Park, YongKeun Optics Depth sectioning in reflection microscopy has predominantly relied on temporal coherence gating. Here we show that volumetric reflection tomography at diffraction-limited resolution can be achieved under monochromatic illumination by engineering spatial, rather than temporal, coherence. In programmable spatial coherence tomography (PSCT), a sequence of pupil-coded illumination patterns with angular-spectrum diversity generates measurement redundancy enabling the system to calibrate itself, jointly retrieving aberrations, illumination profiles, and sample motion without guide stars or modal priors. We demonstrate label-free volumetric imaging of thick human tissues, organoids, frequency-resolved dynamic contrast, and high-resolution in vivo brain imaging through a cranial window. These results position PSCT as an alternative to temporal coherence based reflection imaging in complex biological systems. |
| title | Programmable spatial coherence tomography: diffraction-limited three-dimensional reflection imaging under modulated monochromatic illumination |
| topic | Optics |
| url | https://arxiv.org/abs/2605.05747 |