Biophysical Considerations for Rational Antibody and ADC Design

Fuente: arXiv

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Ocana, Alberto, Espinosa, Jorge R.
Format:	Preprint
Veröffentlicht:	2026
Schlagworte:	Soft Condensed Matter Biological Physics
Online-Zugang:	Acceder al recurso
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge

Unraveling the Molecular Structure of Lipid Nanoparticles through in-silico Self-Assembly for Rational Delivery Design
von: Bai, Xuan, et al.
Veröffentlicht: (2025)

A Soft Penetrable Sphere Colloid Model for the Description of Charge and Excluded Volume Interactions in Antibody Solutions
von: Schurtenberger, Peter, et al.
Veröffentlicht: (2026)

Enhancing Cell Characterization via Hydrodynamic Compression in Suspended Microchannel Resonators
von: Martin-Perez, Alberto, et al.
Veröffentlicht: (2025)

Comparative Silane Surface Functionalization Strategies for Enhanced Bloch Surface Wave Biosensing of Anti-SARS-CoV-2 Antibodies
von: Occhicone, Agostino, et al.
Veröffentlicht: (2026)

Effect of the Protein Corona Formation on Antibody Functionalized Liquid Lipid Nanocarriers
von: Navarro-Marchal, Saul A., et al.
Veröffentlicht: (2024)

Designing complex behaviors using transition-based allosteric self-assembly
von: Metson, Jakob
Veröffentlicht: (2024)

Active topological strings in renewing nematopolar fluids
von: Dinelli, Alberto, et al.
Veröffentlicht: (2026)

Machine Learning Guided Multiscale Design of DNA-functionalized Nanoparticles for Targeted Self-Assembly of the Double Gyroid
von: Nieves-Rosado, Luis, et al.
Veröffentlicht: (2025)

BARCODE: Biomaterial Activity Readouts to Categorize, Optimize, Design and Engineer for high throughput screening and characterization of dynamically restructuring soft materials
von: Chen, Qiaopeng, et al.
Veröffentlicht: (2025)

Genetic interfaces at the frontier of expanding microbial colonies
von: Bauermann, Jonathan, et al.
Veröffentlicht: (2025)

Thin active nematohydrodynamic layers: asymptotic theories and instabilities
von: Nejad, Mehrana R., et al.
Veröffentlicht: (2025)

Spontaneous rotation of active droplets in two and three dimensions
von: Nejad, Mehrana R., et al.
Veröffentlicht: (2023)

Coarse-graining dense, deformable active particles
von: Nejad, Mehrana R., et al.
Veröffentlicht: (2025)

Active chiral rotors: hydrodynamics and chemotaxis
von: Maity, R., et al.
Veröffentlicht: (2025)

Anomalous fluctuations in a droplet of chemically active colloids or enzymes
von: Prathyusha, K. R., et al.
Veröffentlicht: (2024)

Optimal disk packing of chloroplasts in plant cells
von: Schramma, Nico, et al.
Veröffentlicht: (2025)

Quadrupolar active stress induces exotic phases of defect motion in active nematics
von: Sultan, Salik A., et al.
Veröffentlicht: (2021)

Non-additivity in many-body interactions between membrane-deforming spheres increases disorder
von: Azadbakht, Ali, et al.
Veröffentlicht: (2024)

Condensation and activator/repressor control of a transcription-regulated biomolecular liquid
von: Wilken, Sam, et al.
Veröffentlicht: (2024)

Scale-dependent sharpening of interfacial fluctuations in shape-based models of dense cellular sheets
von: Yue, Haicen, et al.
Veröffentlicht: (2024)

Demonstration and interpretation of "scutoid" cells in a quasi-2D soap froth
von: Mughal, A., et al.
Veröffentlicht: (2018)

Cellular dynamics emerging from turbulent flows steered by active filaments
von: Nejad, Mehrana R., et al.
Veröffentlicht: (2025)

Modelling floral and arthropod electrostatics using a two-domain AAA-least squares algorithm
von: Harris, Samuel J., et al.
Veröffentlicht: (2024)

Micro-mechanical response and power-law exponents from the longitudinal fluctuations of F-actin solutions
von: Domínguez-García, Pablo, et al.
Veröffentlicht: (2022)

ATP-induced reconfiguration of the micro-viscoelasticity of cardiac and skeletal myosin solutions
von: Domínguez-García, Pablo, et al.
Veröffentlicht: (2022)

Active Darcy's Law
von: Keogh, Ryan R., et al.
Veröffentlicht: (2023)

Hierarchical friction memory leads to subdiffusive configurational dynamics of fast-folding proteins
von: Klimek, Anton, et al.
Veröffentlicht: (2025)

Unveiling the capabilities of bipolar conical channels in neuromorphic iontronics
von: Kamsma, T. M., et al.
Veröffentlicht: (2023)

Sequence disorder-induced first order phase transition in confined polyelectrolytes
von: Stepanyan, V., et al.
Veröffentlicht: (2024)

Renormalized mechanics and stochastic thermodynamics of growing vesicles
von: Shivers, Jordan L., et al.
Veröffentlicht: (2025)

Space-filling discrete helices
von: Banavar, Jayanth R., et al.
Veröffentlicht: (2025)

Spontaneous flows and interfacial instabilities in oxygen-sensitive living active matter
von: Gholami, Azam, et al.
Veröffentlicht: (2026)

Living Droplets with Mesoscale Swimmers
von: Malik, L., et al.
Veröffentlicht: (2025)

Towards predicting shear-banding instabilities in lipid monolayers
von: Carotenuto, A. R., et al.
Veröffentlicht: (2024)

Evaporation-Induced Pattern Formation and Wetting in Active Microtubule-Kinesin Droplets
von: Nasirimarekani, Vahid, et al.
Veröffentlicht: (2026)

Damage and recovery of flagella in soil bacteria exposed to shear within long microchannels
von: Carrillo-Mora, Juan Pablo, et al.
Veröffentlicht: (2024)

Propagation of Enzyme-driven Active Fluctuations in Crowded Milieu
von: Chakraborty, Rik, et al.
Veröffentlicht: (2024)

Dynamics of Wound Closure in Living Nematic Epithelia
von: Andralojc, Henry, et al.
Veröffentlicht: (2025)

Evidence of robust, universal conformal invariance in living biological matter
von: Andersen, Benjamin H., et al.
Veröffentlicht: (2024)

Motor crosslinking augments elasticity in active nematics
von: Redford, Steven A., et al.
Veröffentlicht: (2023)

if (filemtime($filename) + $maxlifetime < time()) { unlink($filename); $count++; } } return $count; } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ protected function saveSession($sessId, $data): bool { $sessFile = $this->path . '/sess_' . $sessId; if ($handle = fopen($sessFile, 'w')) { $return = false; // Lock the file for exclusive access to avoid issues with multiple // processes writing session simultaneously: if (flock($handle, LOCK_EX)) { $return = fwrite($handle, $data); // Make sure that there's no trailing data by truncating the file to // the correct length: ftruncate($handle, strlen($data)); fflush($handle); flock($handle, LOCK_UN); } fclose($handle); if ($return !== false) { return true; } } // If we got this far, something went wrong with the file output... // It is tempting to throw an exception here, but this code is called // outside of the context of exception handling, so all we can do is // echo a message.

// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

Environment & details:

GET Data empty

POST Data empty

Files empty

Key	Value
language	"de"
VUFIND_SESSION	"57902ef8b0d98f9e7179b4730896f0fa"
ui	"standard"

Session

Key	Value
__Laminas	array:2 [`"_REQUEST_ACCESS_TIME" => 1790847462.5859 "_VALID" => array:1 [ "Laminas\Session\Validator\Id" => "57902ef8b0d98f9e7179b4730896f0fa" ]`]
SessionState	Laminas\Stdlib\ArrayObject {#938}
FlashMessenger	Laminas\Stdlib\ArrayObject {#1433}
SessionHelper	Laminas\Stdlib\ArrayObject {#1759}

Server/Request Data

Key	Value
REDIRECT_VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
REDIRECT_HTTPS	"on"
REDIRECT_SSL_TLS_SNI	"info.umar.mx"
REDIRECT_STATUS	"200"
VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
HTTPS	"on"
SSL_TLS_SNI	"info.umar.mx"
HTTP_ACCEPT	"/"
HTTP_USER_AGENT	"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
HTTP_COOKIE	"language=de; VUFIND_SESSION=57902ef8b0d98f9e7179b4730896f0fa; ui=standard"
HTTP_ACCEPT_ENCODING	"gzip, br, zstd, deflate"
HTTP_HOST	"info.umar.mx"
PATH	"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/snap/bin"
SERVER_SIGNATURE	"<address>Apache/2.4.66 (Ubuntu) Server at info.umar.mx Port 443</address>\n"
SERVER_SOFTWARE	"Apache/2.4.66 (Ubuntu)"
SERVER_NAME	"info.umar.mx"
SERVER_ADDR	"200.23.222.19"
SERVER_PORT	"443"
REMOTE_ADDR	"216.73.216.147"
DOCUMENT_ROOT	"/usr/local/vufind/public"
REQUEST_SCHEME	"https"
CONTEXT_PREFIX	""
CONTEXT_DOCUMENT_ROOT	"/usr/local/vufind/public"
SERVER_ADMIN	"admin@localhost"
SCRIPT_FILENAME	"/usr/local/vufind/public/index.php"
REMOTE_PORT	"57909"
REDIRECT_URL	""" /Record/\n arxiv_https___arxiv_org_abs_2605_16070/Similar """
GATEWAY_INTERFACE	"CGI/1.1"
SERVER_PROTOCOL	"HTTP/1.1"
REQUEST_METHOD	"GET"
QUERY_STRING	""
REQUEST_URI	"/Record/%0Aarxiv_https___arxiv_org_abs_2605_16070/Similar"
SCRIPT_NAME	"/index.php"
PHP_SELF	"/index.php"
REQUEST_TIME_FLOAT	1790847462.5812
REQUEST_TIME	1790847462

Environment Variables empty

Registered Handlers

0. Whoops\Handler\PrettyPageHandler