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Main Authors: Martin-Calle, David, Llamas, Cesar Alvarez, Ros, Vincent Motto-, Dujardin, Christophe, Margueritat, Jérémie, Rodney, David
Format: Preprint
Published: 2026
Subjects:
Online Access:https://arxiv.org/abs/2605.18511
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author Martin-Calle, David
Llamas, Cesar Alvarez
Ros, Vincent Motto-
Dujardin, Christophe
Margueritat, Jérémie
Rodney, David
author_facet Martin-Calle, David
Llamas, Cesar Alvarez
Ros, Vincent Motto-
Dujardin, Christophe
Margueritat, Jérémie
Rodney, David
contents A lightweight and reproducible denoising pipeline for high-throughput Raman spectroscopy is presented. The approach relies on a one-dimensional convolutional autoencoder trained using a Noise2Noise strategy, requiring neither external spectral libraries nor high signal-to-noise reference spectra for training. From a reduced training subset composed of repeated short-exposure acquisitions, the model learns to reconstruct Raman spectra while efficiently suppressing stochastic noise. The method is evaluated on a heterogeneous mineral sample, using both quantitative spectral fidelity metrics (RMSE, SNR, SSIM) and task-oriented criteria based on unsupervised K-means classification. Results demonstrate that integration times as short as 5 ms per spectrum, which are typically insufficient for reliable interpretation, yield denoised spectra with high fidelity to the reference data while preserving chemically coherent maps. This work provides a practical trade-off between spectral quality and acquisition speed, enabling fast, adaptable Raman workflows compatible with routine laboratory use. It also offers a transferable framework for other one-dimensional spectroscopic modalities.
format Preprint
id arxiv_https___arxiv_org_abs_2605_18511
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle A Practical Noise2Noise Denoising Pipeline for High-Throughput Raman Spectroscopy
Martin-Calle, David
Llamas, Cesar Alvarez
Ros, Vincent Motto-
Dujardin, Christophe
Margueritat, Jérémie
Rodney, David
Artificial Intelligence
Materials Science
Signal Processing
A lightweight and reproducible denoising pipeline for high-throughput Raman spectroscopy is presented. The approach relies on a one-dimensional convolutional autoencoder trained using a Noise2Noise strategy, requiring neither external spectral libraries nor high signal-to-noise reference spectra for training. From a reduced training subset composed of repeated short-exposure acquisitions, the model learns to reconstruct Raman spectra while efficiently suppressing stochastic noise. The method is evaluated on a heterogeneous mineral sample, using both quantitative spectral fidelity metrics (RMSE, SNR, SSIM) and task-oriented criteria based on unsupervised K-means classification. Results demonstrate that integration times as short as 5 ms per spectrum, which are typically insufficient for reliable interpretation, yield denoised spectra with high fidelity to the reference data while preserving chemically coherent maps. This work provides a practical trade-off between spectral quality and acquisition speed, enabling fast, adaptable Raman workflows compatible with routine laboratory use. It also offers a transferable framework for other one-dimensional spectroscopic modalities.
title A Practical Noise2Noise Denoising Pipeline for High-Throughput Raman Spectroscopy
topic Artificial Intelligence
Materials Science
Signal Processing
url https://arxiv.org/abs/2605.18511