Physics-informed neural networks for quantitative assessment of cancellous bone microstructure from photoacoustic signals
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arXiv
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| Autores principales: | , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2026
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| Materias: | |
| Acceso en línea: | |
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| _version_ | 1866916031076761600 |
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| author | Lyu, Shoukun Sun, Haohan Nie, Shibo Xie, Weiya Gu, Ying Wu, Shiying Gao, Ya Cheng, Qian |
| author_facet | Lyu, Shoukun Sun, Haohan Nie, Shibo Xie, Weiya Gu, Ying Wu, Shiying Gao, Ya Cheng, Qian |
| contents | Artificial intelligence (AI) empowers innovative diagnostic tools for common diseases, yet its clinical application in skeletal health evaluation is constrained by unsatisfactory accuracy, owing to the inherent porous and poroelastic biophysical features of bone. To address such bottlenecks amid global population aging, this study targets skeletal health and develops a reliable AI framework for precise bone microstructural characterization. We proposed Biot-PINN, a physics-informed neural network embedded with Biot's poroelasticity theory to characterize mechanical responses and wave propagation in poroelastic bone tissues. By decoding photoacoustic signals encoding bone mineral and microstructural features, the framework enables automatic bone microstructural grading. Experimental results reveal that Biot-PINN reaches an accuracy of 97%, markedly surpassing traditional data-driven approaches and providing a robust solution for early skeletal health diagnosis. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2605_21017 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Physics-informed neural networks for quantitative assessment of cancellous bone microstructure from photoacoustic signals Lyu, Shoukun Sun, Haohan Nie, Shibo Xie, Weiya Gu, Ying Wu, Shiying Gao, Ya Cheng, Qian Medical Physics Artificial intelligence (AI) empowers innovative diagnostic tools for common diseases, yet its clinical application in skeletal health evaluation is constrained by unsatisfactory accuracy, owing to the inherent porous and poroelastic biophysical features of bone. To address such bottlenecks amid global population aging, this study targets skeletal health and develops a reliable AI framework for precise bone microstructural characterization. We proposed Biot-PINN, a physics-informed neural network embedded with Biot's poroelasticity theory to characterize mechanical responses and wave propagation in poroelastic bone tissues. By decoding photoacoustic signals encoding bone mineral and microstructural features, the framework enables automatic bone microstructural grading. Experimental results reveal that Biot-PINN reaches an accuracy of 97%, markedly surpassing traditional data-driven approaches and providing a robust solution for early skeletal health diagnosis. |
| title | Physics-informed neural networks for quantitative assessment of cancellous bone microstructure from photoacoustic signals |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2605.21017 |