Security in the Fine-Tuning Lifecycle of Large Language Models: Threats, Defenses,Evaluation, and Future Directions

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Main Authors: Li, Wenjuan, Liu, Yitao, Chen, Runze, Buyya, Rajkumar
Format: Preprint
Published: 2026
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author Li, Wenjuan
Liu, Yitao
Chen, Runze
Buyya, Rajkumar
author_facet Li, Wenjuan
Liu, Yitao
Chen, Runze
Buyya, Rajkumar
contents Background: Fine-tuning is central to adapting pre-trained Large Language Models (LLMs) to downstream tasks, but its reliance on training data, parameter updates, and reusable components opens entry points for attackers. Threats have evolved from data poisoning and weight tampering to agent manipulation and interface exploitation, yet existing reviews lack a unified framework spanning the full fine-tuning lifecycle. Objective: This paper presents a systematic survey of LLM fine-tuning security and establishes a lifecycle-based framework for comparing attacks and defenses, complemented by unified empirical evaluation. Methods: We divide attack and defense mechanisms into three phases by intervention timing: pre-tuning, during-tuning, and post-tuning. Within each phase, strategies are reviewed and contrasted to expose their evolution and limitations. Representative methods are then evaluated under a unified model, hardware, and protocol setup, with cross-phase experiments pairing attacks and defenses from different phases. Results: Attack effectiveness is highly model-dependent and non-monotonic with scale: weight-editing attacks effective on earlier models lose impact on modern open-source LLMs; cross-lingual backdoor transfer, reported as near-perfect at larger scales, fails entirely on tested 1B-4B models; and purely benign samples can compromise safety alignment in instruction-tuned models. Single-phase defenses rarely generalize across phases, and defense effectiveness depends jointly on model architecture and alignment state. Conclusion: We identify key open problems (configuration-robust defense, cross-phase defense composition, and embedding-space attacks beyond behavioral assumptions) and propose concrete future research directions.
format Preprint
id arxiv_https___arxiv_org_abs_2605_25073
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Security in the Fine-Tuning Lifecycle of Large Language Models: Threats, Defenses,Evaluation, and Future Directions
Li, Wenjuan
Liu, Yitao
Chen, Runze
Buyya, Rajkumar
Cryptography and Security
Artificial Intelligence
Machine Learning
Background: Fine-tuning is central to adapting pre-trained Large Language Models (LLMs) to downstream tasks, but its reliance on training data, parameter updates, and reusable components opens entry points for attackers. Threats have evolved from data poisoning and weight tampering to agent manipulation and interface exploitation, yet existing reviews lack a unified framework spanning the full fine-tuning lifecycle. Objective: This paper presents a systematic survey of LLM fine-tuning security and establishes a lifecycle-based framework for comparing attacks and defenses, complemented by unified empirical evaluation. Methods: We divide attack and defense mechanisms into three phases by intervention timing: pre-tuning, during-tuning, and post-tuning. Within each phase, strategies are reviewed and contrasted to expose their evolution and limitations. Representative methods are then evaluated under a unified model, hardware, and protocol setup, with cross-phase experiments pairing attacks and defenses from different phases. Results: Attack effectiveness is highly model-dependent and non-monotonic with scale: weight-editing attacks effective on earlier models lose impact on modern open-source LLMs; cross-lingual backdoor transfer, reported as near-perfect at larger scales, fails entirely on tested 1B-4B models; and purely benign samples can compromise safety alignment in instruction-tuned models. Single-phase defenses rarely generalize across phases, and defense effectiveness depends jointly on model architecture and alignment state. Conclusion: We identify key open problems (configuration-robust defense, cross-phase defense composition, and embedding-space attacks beyond behavioral assumptions) and propose concrete future research directions.
title Security in the Fine-Tuning Lifecycle of Large Language Models: Threats, Defenses,Evaluation, and Future Directions
topic Cryptography and Security
Artificial Intelligence
Machine Learning
url https://arxiv.org/abs/2605.25073