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| Autori principali: | , , , , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2026
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| Soggetti: | |
| Accesso online: | https://arxiv.org/abs/2605.25250 |
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| _version_ | 1866917530213285888 |
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| author | Li, Leshu Lu, An Wang, Haiyu Feng, Zhibin Duan, Conghui Bao, Qing Zhao, Zongmin Zhang, Sai Qian |
| author_facet | Li, Leshu Lu, An Wang, Haiyu Feng, Zhibin Duan, Conghui Bao, Qing Zhao, Zongmin Zhang, Sai Qian |
| contents | Lipid nanoparticles (LNPs) are among the most clinically mature platforms for nucleic acid delivery, yet designing lipids that are both effective and biologically safe remains a major bottleneck. In practical screening, toxicity is a decision-level constraint: if a lipid is toxic, its efficiency prediction is clinically irrelevant. We propose LipoAgent, a safety-aware multi-agent LLM framework for lipid discovery. LipoAgent combines domain-specific finetuning with a conditional prediction objective that enforces toxicity as a prerequisite for efficiency prediction, and further improves reliability via multi-agent verification with lightweight human oversight when disagreement persists. Across multiple foundation models, LipoAgent achieves an average 32% relative improvement in mRNA transfection efficiency prediction compared with other reported models for lipid design. Wet-lab validation confirms that virtual screening rankings reliably translate to biological transfection outcomes. The code is publicly available at https://github.com/SAI-Lab-NYU/LipoAgent.git. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2605_25250 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | LipoAgent: Coordinating Fine-Tuned LLM Agents for Safer Lipid Design Li, Leshu Lu, An Wang, Haiyu Feng, Zhibin Duan, Conghui Bao, Qing Zhao, Zongmin Zhang, Sai Qian Artificial Intelligence Lipid nanoparticles (LNPs) are among the most clinically mature platforms for nucleic acid delivery, yet designing lipids that are both effective and biologically safe remains a major bottleneck. In practical screening, toxicity is a decision-level constraint: if a lipid is toxic, its efficiency prediction is clinically irrelevant. We propose LipoAgent, a safety-aware multi-agent LLM framework for lipid discovery. LipoAgent combines domain-specific finetuning with a conditional prediction objective that enforces toxicity as a prerequisite for efficiency prediction, and further improves reliability via multi-agent verification with lightweight human oversight when disagreement persists. Across multiple foundation models, LipoAgent achieves an average 32% relative improvement in mRNA transfection efficiency prediction compared with other reported models for lipid design. Wet-lab validation confirms that virtual screening rankings reliably translate to biological transfection outcomes. The code is publicly available at https://github.com/SAI-Lab-NYU/LipoAgent.git. |
| title | LipoAgent: Coordinating Fine-Tuned LLM Agents for Safer Lipid Design |
| topic | Artificial Intelligence |
| url | https://arxiv.org/abs/2605.25250 |