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| Main Authors: | , , , , , , , |
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| Format: | Preprint |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2605.27583 |
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| _version_ | 1866910263672832000 |
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| author | Nguyen, Phu X. Kontras, Konstantinos Dai, Wei Phan, Huy Chatzichristos, Christos Liang, Paul Pu Vandenberk, Bert De Vos, Maarten |
| author_facet | Nguyen, Phu X. Kontras, Konstantinos Dai, Wei Phan, Huy Chatzichristos, Christos Liang, Paul Pu Vandenberk, Bert De Vos, Maarten |
| contents | Electrocardiograms (ECGs) are widely used non-invasive measurements of cardiac activity and play a central role in clinical diagnosis. Recent multimodal approaches align ECG signals with clinical reports to incorporate diagnostic semantics, but clinical reports often fail to preserve the rich physiological structure of ECG waveforms, particularly across multiple levels of abstraction ranging from coarse diagnostic categories to fine-grained morphology. To address this limitation, we formulate ECG representation learning from an information-theoretic perspective and derive a tractable objective that jointly preserves signal structure and integrates clinical semantics. Based on this principle, we propose \textbf{MERIT} (Multimodal ECG Representation via Information Theory), a dual-branch pretraining framework combining masked ECG modeling with ECG--text contrastive alignment. Extensive experiments on PTB-XL and additional benchmarks demonstrate consistent improvements over prior methods, including gains exceeding $3%$ F1 on PTB-XL All and $5%$ F1 on SubClass classification. In zero-shot evaluation, MERIT further improves performance by up to $ +2.66\%$ AUC and $ +2.11\%$ F1 on PTB-XL SubClass, while also demonstrating robustness under multiple distribution-shift settings. Moreover, leveraging the learned ECG representations for ECG-conditioned clinical text generation with large language models improves text quality across several metrics, including ROUGE and METEOR. Together, these results demonstrate that MERIT learns more informative and clinically meaningful ECG representations, particularly for fine-grained clinical applications. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2605_27583 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Information-theoretic Multimodal Representation Learning for Electrocardiogram Signals Nguyen, Phu X. Kontras, Konstantinos Dai, Wei Phan, Huy Chatzichristos, Christos Liang, Paul Pu Vandenberk, Bert De Vos, Maarten Machine Learning Electrocardiograms (ECGs) are widely used non-invasive measurements of cardiac activity and play a central role in clinical diagnosis. Recent multimodal approaches align ECG signals with clinical reports to incorporate diagnostic semantics, but clinical reports often fail to preserve the rich physiological structure of ECG waveforms, particularly across multiple levels of abstraction ranging from coarse diagnostic categories to fine-grained morphology. To address this limitation, we formulate ECG representation learning from an information-theoretic perspective and derive a tractable objective that jointly preserves signal structure and integrates clinical semantics. Based on this principle, we propose \textbf{MERIT} (Multimodal ECG Representation via Information Theory), a dual-branch pretraining framework combining masked ECG modeling with ECG--text contrastive alignment. Extensive experiments on PTB-XL and additional benchmarks demonstrate consistent improvements over prior methods, including gains exceeding $3%$ F1 on PTB-XL All and $5%$ F1 on SubClass classification. In zero-shot evaluation, MERIT further improves performance by up to $ +2.66\%$ AUC and $ +2.11\%$ F1 on PTB-XL SubClass, while also demonstrating robustness under multiple distribution-shift settings. Moreover, leveraging the learned ECG representations for ECG-conditioned clinical text generation with large language models improves text quality across several metrics, including ROUGE and METEOR. Together, these results demonstrate that MERIT learns more informative and clinically meaningful ECG representations, particularly for fine-grained clinical applications. |
| title | Information-theoretic Multimodal Representation Learning for Electrocardiogram Signals |
| topic | Machine Learning |
| url | https://arxiv.org/abs/2605.27583 |