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Hauptverfasser: Hou, Ruihui, Huai, Ziyue, Zhang, Chennuo, Liu, Ziyan, Zhao, Siran, Yu, Yao, Zhai, Jie, Ruan, Tong
Format: Preprint
Veröffentlicht: 2026
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Online-Zugang:https://arxiv.org/abs/2606.01094
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author Hou, Ruihui
Huai, Ziyue
Zhang, Chennuo
Liu, Ziyan
Zhao, Siran
Yu, Yao
Zhai, Jie
Ruan, Tong
author_facet Hou, Ruihui
Huai, Ziyue
Zhang, Chennuo
Liu, Ziyan
Zhao, Siran
Yu, Yao
Zhai, Jie
Ruan, Tong
contents Clinical order generation serves as a critical bridge between clinical decision-making and real-world practice, translating medical decisions into concrete and executable orders. Existing agents mainly focus on coarse-grained decisions and overlook the fine-grained, executable information required for clinical orders. To address this gap, we propose CAREAgent, an agent for clinical order generation. To support its training, we introduce a two-stage agentic reasoning data construction method. First, we design an agent framework that constructs verifiable reasoning trajectories aligned with realistic clinical tool usage. Second, we filter reasoning trajectories by format compliance, order validity, and clinical plausibility. Building on the constructed data, the model is first trained via supervised fine-tuning to acquire fundamental reasoning formats and medical knowledge, and is subsequently optimized through reinforcement learning with multi-dimensional reward functions to enhance complex clinical reasoning capabilities. Experiments on multiple benchmarks demonstrate the effectiveness of CAREAgent. On ClinicalBench (unseen during training), CAREAgent improves the F1 score by 5.05%, 2.09%, and 0.86% over the single-agent, multi-agent, and agentic reasoning methods, respectively.
format Preprint
id arxiv_https___arxiv_org_abs_2606_01094
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle CAREAgent: Clinical Agent with Structured Reasoning and Tool-Integrated for Order Generation
Hou, Ruihui
Huai, Ziyue
Zhang, Chennuo
Liu, Ziyan
Zhao, Siran
Yu, Yao
Zhai, Jie
Ruan, Tong
Artificial Intelligence
Clinical order generation serves as a critical bridge between clinical decision-making and real-world practice, translating medical decisions into concrete and executable orders. Existing agents mainly focus on coarse-grained decisions and overlook the fine-grained, executable information required for clinical orders. To address this gap, we propose CAREAgent, an agent for clinical order generation. To support its training, we introduce a two-stage agentic reasoning data construction method. First, we design an agent framework that constructs verifiable reasoning trajectories aligned with realistic clinical tool usage. Second, we filter reasoning trajectories by format compliance, order validity, and clinical plausibility. Building on the constructed data, the model is first trained via supervised fine-tuning to acquire fundamental reasoning formats and medical knowledge, and is subsequently optimized through reinforcement learning with multi-dimensional reward functions to enhance complex clinical reasoning capabilities. Experiments on multiple benchmarks demonstrate the effectiveness of CAREAgent. On ClinicalBench (unseen during training), CAREAgent improves the F1 score by 5.05%, 2.09%, and 0.86% over the single-agent, multi-agent, and agentic reasoning methods, respectively.
title CAREAgent: Clinical Agent with Structured Reasoning and Tool-Integrated for Order Generation
topic Artificial Intelligence
url https://arxiv.org/abs/2606.01094