Destruction of CD4 T Lymphocytes Alone Cannot Account for their Long-term Decrease in AIDS
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arXiv
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| Format: | Preprint |
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2000
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| _version_ | 1866914099206553600 |
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| author | Louzoun, Yoram Cohen, Irun. R. Atlan, Henri |
| author_facet | Louzoun, Yoram Cohen, Irun. R. Atlan, Henri |
| contents | Following previous models describing a quasi steady state (QSS) for the evolution of HIV infection and AIDS, we have developed a larger formalism simulating the long-term evolution of the QSS We show that the long-term evolution of AIDS cannot be explained by the destruction alone of CD4 T cells, either directly or indirectly. The destruction of CD4 T cells can lead only to a QSS with a lower concentration of CD4 T cells, but CD4 destruction cannot generate the sustained long-term decrease in T cells leading to AIDS. We here suggest some workable explanations. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_math_0008052 |
| institution | arXiv |
| publishDate | 2000 |
| record_format | arxiv |
| spellingShingle | Destruction of CD4 T Lymphocytes Alone Cannot Account for their Long-term Decrease in AIDS Louzoun, Yoram Cohen, Irun. R. Atlan, Henri Dynamical Systems Numerical Analysis Mathematical Physics Quantitative Biology Following previous models describing a quasi steady state (QSS) for the evolution of HIV infection and AIDS, we have developed a larger formalism simulating the long-term evolution of the QSS We show that the long-term evolution of AIDS cannot be explained by the destruction alone of CD4 T cells, either directly or indirectly. The destruction of CD4 T cells can lead only to a QSS with a lower concentration of CD4 T cells, but CD4 destruction cannot generate the sustained long-term decrease in T cells leading to AIDS. We here suggest some workable explanations. |
| title | Destruction of CD4 T Lymphocytes Alone Cannot Account for their Long-term Decrease in AIDS |
| topic | Dynamical Systems Numerical Analysis Mathematical Physics Quantitative Biology |
| url | https://arxiv.org/abs/math/0008052 |