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| Main Authors: | , , , |
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| Format: | Recurso educativo Open Access |
| Language: | en |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://eric.ed.gov/?id=EJ920483 |
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Table of Contents:
- Synthesis of Aryl-Substituted 2,4-Dinitrophenylamines: Nucleophilic Aromatic Substitution as a Problem-Solving and Collaborative-Learning Approach Santos, Elvira Santos Garcia, Irma Cruz Gavilan Gomez, Eva Florencia Lejarazo Vilchis-Reyes, Miguel Angel Problem Solving College Science Science Instruction Scientific Principles Teaching Methods Cooperative Learning Science Experiments Data Analysis Science Process Skills Science Laboratories Chemistry A series of experiments based on problem-solving and collaborative-learning pedagogies are described that encourage students to interpret results and draw conclusions from data. Different approaches including parallel library synthesis, solvent variation, and leaving group variation are used to study a nucleophilic aromatic substitution of 1-halo-2,4-dinitrobenzene to obtain aryl-substituted 2,4-dinitrophenylamines. Determining the yield of each reaction in parallel synthesis allows students to make simple structure-reactivity relationships. (Contains 3 figures and 1 scheme.)