(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland
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| Natura: | Dataset Open Access |
| Lingua: | en |
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PANGAEA
2008
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| _version_ | 1867170960309747712 |
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| author | Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J |
| author_facet | Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J |
| collection | Datos científicos de ciencias marinas y ambientales |
| contents | The tissue-specific composition of sum classes of brominated and chlorinated contaminants and metabolic/degradation byproducts was determined in adult male and female polar bears from East Greenland. Significantly (p < 0.05) higher concentrations of SUM-PCBs, various other organochlorines such as SUM-CHL, p,p'-DDE, SUM-CBz, SUM-HCHs, octachlorostyrene (OCS),SUM-mirex, dieldrin, the flame retardants SUM-PBDEs, and total-(R)-hexabromocyclododecane (HBCD), SUM-methylsulfonyl (MeSO2)-PCBs and 3-MeSO2-p,p'-DDE, were found in the adipose and liver tissues relative to whole blood and brain. In contrast, SUM-hydroxyl (OH)-PCB, 4-OH-heptachlorostyrene and SUM-OH-PBDE concentrations were significantly highest (p < 0.05) in whole blood, whereas the highest concentrations of SUM-OH-PBBs were found in the adipose tissue. Based on the total concentrations of all organohalogens in all three tissues and blood, the combined body burden was estimated to be 1.34 ± 0.12 g, where >91% of this amount was accounted for by the adipose tissue alone, followed by the liver, whole blood, and brain. These results show that factors such as protein association and lipid solubility appear to be differentially influencing the toxicokinetics, in terms of tissue composition/localization and burden, of organohalogen classes with respect to chemical structure and properties such as the type of halogenation (e.g., chlorination or bromination), and the presence or absence of additional phenyl group substituents (e.g., MeO and OH groups). The tissue- and blood-specific accumulation (or retention) among organohalogen classes indicates that exposure and any potential contaminant-mediated effects in these polar bears are likely tissue or blood specific. |
| format | Dataset Open Access |
| id | pangaea_https___doi_org_10_1594_PANGAEA_810194 |
| institution | PANGAEA |
| language | en |
| publishDate | 2008 |
| publisher | PANGAEA |
| record_format | pangaea |
| spellingShingle | (Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J 3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene; 4-hydroxy-heptachlorostyrene; 4-hydroxy-heptachlorostyrene, standard deviation; alpha-Hexabromocyclododecane; Chlordane; Chlordane, standard deviation; Chlorinated benzene; Chlorinated benzene, standard deviation; Dichlorodiphenyldichloroethylene, standard deviation; Dieldrin; Dieldrin, standard deviation; East_Greenland; East Greenland; Hexabromocyclododecane, standard deviation; Hexachlorocyclohexane; Hexachlorocyclohexane, standard deviation; Hydroxylated polybrominated biphenyl; Hydroxylated polybrominated biphenyl, standard deviation; Hydroxylated polybrominated diphenyl ethers; Hydroxylated polybrominated diphenyl ethers, standard deviation; Hydroxy-polychlorinated biphenyl; Hydroxy-polychlorinated biphenyl, standard deviation; International Polar Year (2007-2008); IPY; Lipids; Lipids, standard deviation; Methoxylated polybrominated diphenyl ethers; Methyl sulfone polychlorinated biphenyl; Methyl sulfone polychlorinated biphenyl, standard deviation; Mirex; Mirex, standard deviation; Octachlorostyrene; Octachlorostyrene, standard deviation; para,para-Dichlorodiphenyldichloroethylene; Pentachlorophenol; Pentachlorophenol, standard deviation; Polybrominated diphenyl ethers; Polybrominated diphenyl ethers, standard deviation; Polychlorinated biphenyl; Polychlorinated biphenyl, standard deviation; Sample type The tissue-specific composition of sum classes of brominated and chlorinated contaminants and metabolic/degradation byproducts was determined in adult male and female polar bears from East Greenland. Significantly (p < 0.05) higher concentrations of SUM-PCBs, various other organochlorines such as SUM-CHL, p,p'-DDE, SUM-CBz, SUM-HCHs, octachlorostyrene (OCS),SUM-mirex, dieldrin, the flame retardants SUM-PBDEs, and total-(R)-hexabromocyclododecane (HBCD), SUM-methylsulfonyl (MeSO2)-PCBs and 3-MeSO2-p,p'-DDE, were found in the adipose and liver tissues relative to whole blood and brain. In contrast, SUM-hydroxyl (OH)-PCB, 4-OH-heptachlorostyrene and SUM-OH-PBDE concentrations were significantly highest (p < 0.05) in whole blood, whereas the highest concentrations of SUM-OH-PBBs were found in the adipose tissue. Based on the total concentrations of all organohalogens in all three tissues and blood, the combined body burden was estimated to be 1.34 ± 0.12 g, where >91% of this amount was accounted for by the adipose tissue alone, followed by the liver, whole blood, and brain. These results show that factors such as protein association and lipid solubility appear to be differentially influencing the toxicokinetics, in terms of tissue composition/localization and burden, of organohalogen classes with respect to chemical structure and properties such as the type of halogenation (e.g., chlorination or bromination), and the presence or absence of additional phenyl group substituents (e.g., MeO and OH groups). The tissue- and blood-specific accumulation (or retention) among organohalogen classes indicates that exposure and any potential contaminant-mediated effects in these polar bears are likely tissue or blood specific. |
| title | (Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland |
| topic | 3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene; 4-hydroxy-heptachlorostyrene; 4-hydroxy-heptachlorostyrene, standard deviation; alpha-Hexabromocyclododecane; Chlordane; Chlordane, standard deviation; Chlorinated benzene; Chlorinated benzene, standard deviation; Dichlorodiphenyldichloroethylene, standard deviation; Dieldrin; Dieldrin, standard deviation; East_Greenland; East Greenland; Hexabromocyclododecane, standard deviation; Hexachlorocyclohexane; Hexachlorocyclohexane, standard deviation; Hydroxylated polybrominated biphenyl; Hydroxylated polybrominated biphenyl, standard deviation; Hydroxylated polybrominated diphenyl ethers; Hydroxylated polybrominated diphenyl ethers, standard deviation; Hydroxy-polychlorinated biphenyl; Hydroxy-polychlorinated biphenyl, standard deviation; International Polar Year (2007-2008); IPY; Lipids; Lipids, standard deviation; Methoxylated polybrominated diphenyl ethers; Methyl sulfone polychlorinated biphenyl; Methyl sulfone polychlorinated biphenyl, standard deviation; Mirex; Mirex, standard deviation; Octachlorostyrene; Octachlorostyrene, standard deviation; para,para-Dichlorodiphenyldichloroethylene; Pentachlorophenol; Pentachlorophenol, standard deviation; Polybrominated diphenyl ethers; Polybrominated diphenyl ethers, standard deviation; Polychlorinated biphenyl; Polychlorinated biphenyl, standard deviation; Sample type |
| url | https://doi.org/10.1594/PANGAEA.810194 |