Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber
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| Auteurs principaux: | , , , , , , , |
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| Format: | Dataset Open Access |
| Langue: | en |
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PANGAEA
2011
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| _version_ | 1867171365852807168 |
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| author | Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe |
| author_facet | Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe |
| collection | Datos científicos de ciencias marinas y ambientales |
| contents | As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SumDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone dynamics. |
| format | Dataset Open Access |
| id | pangaea_https___doi_org_10_1594_PANGAEA_812009 |
| institution | PANGAEA |
| language | en |
| publishDate | 2011 |
| publisher | PANGAEA |
| record_format | pangaea |
| spellingShingle | Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe Aasiaat_Canis; Biological sample; BIOS; Disko Bay, Greenland; International Polar Year (2007-2008); IPY As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SumDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone dynamics. |
| title | Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber |
| topic | Aasiaat_Canis; Biological sample; BIOS; Disko Bay, Greenland; International Polar Year (2007-2008); IPY |
| url | https://doi.org/10.1594/PANGAEA.812009 |