(Table 1) Polychlorinated biphenyl (PCB) and PCB metabolite concentrations in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea
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| Formato: | Dataset Open Access |
| Lenguaje: | en |
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PANGAEA
2008
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| _version_ | 1867172327764000768 |
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| author | Routti, Heli Letcher, Robert J Arukwe, Augustine van Bavel, Bert Yoccoz, Nigel G Chu, Shaogang Gabrielsen, Geir W |
| author_facet | Routti, Heli Letcher, Robert J Arukwe, Augustine van Bavel, Bert Yoccoz, Nigel G Chu, Shaogang Gabrielsen, Geir W |
| collection | Datos científicos de ciencias marinas y ambientales |
| contents | Polychlorinated biphenyls (PCBs) may induce activity of hepatic enzymes, mainly Phase I monooxygenases and conjugating Phase II enzymes, that catalyze the metabolism of PCBs leading to formation of metabolites and to potential adverse health effects. The present study investigates the concentration and pattern of PCBs, the induction of hepatic phase I and II enzymes, and the formation of hydroxy (OH) and methylsulfonyl (CH3SO2=MeSO2) PCB metabolites in two ringed seal (Phoca hispida) populations, which are contrasted by the degree of contamination exposure, that is, highly contaminated Baltic Sea (n = 31) and less contaminated Svalbard (n = 21). Phase I enzymes were measured as ethoxyresorufin-O-deethylation (EROD), benzyloxyresorufin-O-dealkylation (BROD), methoxyresorufin-O-demethylation (MROD), and pentoxyresorufin-O-dealkylation (PROD) activities, and phase II enzymes were measured as uridine diphosphophate glucuronosyl transferase (UDPGT) and glutathione-S-transferase (GST). Geographical comparison, multivariate, and correlation analysis indicated that sum-PCB had a positive impact on Phase I enzyme and GST activities leading to biotransformation of group III (vicinal ortho-meta-H atoms and <=1 ortho-chlorine (Cl)) and IV PCBs (vicinal meta-para-H atoms and <=2 ortho-Cl). The potential precursors for the main OH-PCBs detected in plasma in the Baltic seals were group III PCBs. MeSO2-PCBs detected in liver were mainly products of group IV PCB metabolism. Both CYP1A- and CYP2B-like enzymes are suggested to be involved in the PCB biotransformation in ringed seals. |
| format | Dataset Open Access |
| id | pangaea_https___doi_org_10_1594_PANGAEA_819407 |
| institution | PANGAEA |
| language | en |
| publishDate | 2008 |
| publisher | PANGAEA |
| record_format | pangaea |
| spellingShingle | (Table 1) Polychlorinated biphenyl (PCB) and PCB metabolite concentrations in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea Routti, Heli Letcher, Robert J Arukwe, Augustine van Bavel, Bert Yoccoz, Nigel G Chu, Shaogang Gabrielsen, Geir W Age, relative, number of years; Age, standard deviation; Area/locality; Baltic Sea; BalticSea_Bothnia; Biological sample; BIOS; Event label; Female; Hydroxy-polychlorinated biphenyl; Hydroxy-polychlorinated biphenyl, standard deviation; International Polar Year (2007-2008); IPY; Lipids; Lipids, standard deviation; Male; Methyl sulfone polychlorinated biphenyl; Methyl sulfone polychlorinated biphenyl, standard deviation; MULT; Multiple investigations; Polychlorinated biphenyl; Polychlorinated biphenyl, standard deviation; Sample amount, subset; Sample type; Sampling date; Species; Species, common name; Svalbard Polychlorinated biphenyls (PCBs) may induce activity of hepatic enzymes, mainly Phase I monooxygenases and conjugating Phase II enzymes, that catalyze the metabolism of PCBs leading to formation of metabolites and to potential adverse health effects. The present study investigates the concentration and pattern of PCBs, the induction of hepatic phase I and II enzymes, and the formation of hydroxy (OH) and methylsulfonyl (CH3SO2=MeSO2) PCB metabolites in two ringed seal (Phoca hispida) populations, which are contrasted by the degree of contamination exposure, that is, highly contaminated Baltic Sea (n = 31) and less contaminated Svalbard (n = 21). Phase I enzymes were measured as ethoxyresorufin-O-deethylation (EROD), benzyloxyresorufin-O-dealkylation (BROD), methoxyresorufin-O-demethylation (MROD), and pentoxyresorufin-O-dealkylation (PROD) activities, and phase II enzymes were measured as uridine diphosphophate glucuronosyl transferase (UDPGT) and glutathione-S-transferase (GST). Geographical comparison, multivariate, and correlation analysis indicated that sum-PCB had a positive impact on Phase I enzyme and GST activities leading to biotransformation of group III (vicinal ortho-meta-H atoms and <=1 ortho-chlorine (Cl)) and IV PCBs (vicinal meta-para-H atoms and <=2 ortho-Cl). The potential precursors for the main OH-PCBs detected in plasma in the Baltic seals were group III PCBs. MeSO2-PCBs detected in liver were mainly products of group IV PCB metabolism. Both CYP1A- and CYP2B-like enzymes are suggested to be involved in the PCB biotransformation in ringed seals. |
| title | (Table 1) Polychlorinated biphenyl (PCB) and PCB metabolite concentrations in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea |
| topic | Age, relative, number of years; Age, standard deviation; Area/locality; Baltic Sea; BalticSea_Bothnia; Biological sample; BIOS; Event label; Female; Hydroxy-polychlorinated biphenyl; Hydroxy-polychlorinated biphenyl, standard deviation; International Polar Year (2007-2008); IPY; Lipids; Lipids, standard deviation; Male; Methyl sulfone polychlorinated biphenyl; Methyl sulfone polychlorinated biphenyl, standard deviation; MULT; Multiple investigations; Polychlorinated biphenyl; Polychlorinated biphenyl, standard deviation; Sample amount, subset; Sample type; Sampling date; Species; Species, common name; Svalbard |
| url | https://doi.org/10.1594/PANGAEA.819407 |