Indirect effects of climate changes on cadmium bioavailability and biological effects in the Mediterranean mussel Mytilus galloprovincialis
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| Natura: | Dataset Open Access |
| Lingua: | en |
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PANGAEA
2017
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| author | Nardi, Alessandro Mincarelli, Luana Fiorella Benedetti, Maura Fattorini, Daniele d'Errico, Giuseppe Regoli, Francesco |
| author_facet | Nardi, Alessandro Mincarelli, Luana Fiorella Benedetti, Maura Fattorini, Daniele d'Errico, Giuseppe Regoli, Francesco |
| collection | Datos científicos de ciencias marinas y ambientales |
| contents | Despite the great interest in the consequences of climate change on the physiological functioning of marine organisms, indirect and interactive effects of rising temperature and pCO2 on bioaccumulation and responsiveness to environmental pollutants are still poorly explored, particularly in terms of cellular mechanisms. According to future projections of temperature and pH/pCO2, this study investigated the main cellular pathways involved in metal detoxification and oxidative homeostasis in Mediterranean mussels, Mytilus galloprovincialis, exposed for 4 weeks to various combinations of two levels of pH/pCO2 (8.2/400 µatm and 7.4/3000 µatm), temperature (20 and 25 °C), and cadmium addition (0 and 20 µg/L). Bioaccumulation was increased in metal exposed organisms but it was not further modulated by different temperature and pH/pCO2 combinations. However, interactions between temperature, pH and cadmium had significant effects on induction of metallothioneins, responses of the antioxidant system and the onset of oxidative damages, which was tissue dependent. Multiple stressors increased metallothioneins concentrations in the digestive gland revealing different oxidative effects: while temperature and cadmium enhanced glutathione-dependent antioxidant protection and capability to neutralize peroxyl radicals, the metal increased the accumulation of lipid peroxidation products under acidified conditions. Gills did not reveal specific effects for different combinations of factors, but a general stress condition was observed in this tissue after various treatments. Significant variations of immune system were mainly caused by increased temperature and low pH, while co-exposure to acidification and cadmium enhanced metal genotoxicity and the onset of permanent DNA damage in haemocytes. Elaboration of the whole biomarker data in a cellular hazard index, corroborated the synergistic effects of temperature and acidification which increased the toxicological effects of cadmium. The overall results confirmed that climate change could influence ecotoxicological effects of environmental contaminants, highlighting the importance of a better knowledge of cellular mechanisms to understand and predict responsiveness of marine organisms to such multiple stressors. |
| format | Dataset Open Access |
| id | pangaea_https___doi_org_10_1594_PANGAEA_872084 |
| institution | PANGAEA |
| language | en |
| publishDate | 2017 |
| publisher | PANGAEA |
| record_format | pangaea |
| spellingShingle | Indirect effects of climate changes on cadmium bioavailability and biological effects in the Mediterranean mussel Mytilus galloprovincialis Nardi, Alessandro Mincarelli, Luana Fiorella Benedetti, Maura Fattorini, Daniele d'Errico, Giuseppe Regoli, Francesco Adriatic_Sea; Alkalinity, total; Alkalinity, total, standard deviation; Animalia; Aragonite saturation state; Aragonite saturation state, standard deviation; Benthic animals; Benthos; Bicarbonate ion; Bottles or small containers/Aquaria (<20 L); Cadmium; Cadmium, standard deviation; Calcite saturation state; Calcite saturation state, standard deviation; Calculated using CO2SYS; Calculated using seacarb after Nisumaa et al. (2010); Carbon, inorganic, dissolved; Carbonate ion; Carbonate system computation flag; Carbon dioxide; Catalase activity, per protein mass; Catalase activity, standard deviation; Coast and continental shelf; EXP; Experiment; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Glutathione, total, per unit wet mass; Glutathione, total, per unit wet mass, standard deviation; Glutathione reductase, per protein mass; Glutathione reductase, unit per protein mass, standard deviation; Glutathione S-transferase, activity per protein mass; Glutathione S-transferase, activity per protein mass, standard deviation; Granulocytes/Hyalinocytes ratio; Granulocytes/Hyalinocytes ratio, standard deviation; Hemocytes DNA strand breaks; Hemocytes DNA strand breaks, standard deviation; Hemocytes lysosomal membranes stability; Hemocytes lysosomal membranes stability, standard deviation; Hemocytes micronuclei frequency; Hemocytes micronuclei frequency, standard deviation; Incubation duration; Inorganic toxins; Laboratory experiment; Lipofuscin; Lipofuscin, standard deviation; Malondialdehyde, per wet mass; Malondialdehyde, per wet mass, standard deviation; Mediterranean Sea; Metallothionein, per protein mass; Metallothionein per protein, standard deviation; Mollusca; Mytilus galloprovincialis; Neutral lipids; Neutral lipids, standard deviation; OA-ICC; Ocean acidification; Ocean Acidification International Coordination Centre; Partial pressure of carbon dioxide, standard deviation; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); pH, NBS scale; pH, standard deviation; pH, total scale; Phagocytosis rate; Phagocytosis rate, standard deviation; Potentiometric; Potentiometric titration; Registration number of species; Salinity; Salinity, standard deviation; Sample code/label; Selenium dependent glutathione peroxidases activity, per protein mass; Selenium dependent glutathione peroxidases activity, unit per protein mass, standard deviation; Single species; Species; Temperate; Temperature; Temperature, water; Temperature, water, standard deviation; Total glutathione peroxidases activity, per protein mass; Total glutathione peroxidases activity, unit per protein mass, standard deviation; Total oxyradical scavenging capacity against hydroxyl radicals, unit per protein mass; Total oxyradical scavenging capacity against hydroxyl radicals, unit per protein mass, standard deviation; Total oxyradical scavenging capacity against peroxyl radicals, unit per protein mass; Total oxyradical scavenging capacity against peroxyl radicals, unit per protein mass, standard deviation; Treatment; Type; Uniform resource locator/link to reference Despite the great interest in the consequences of climate change on the physiological functioning of marine organisms, indirect and interactive effects of rising temperature and pCO2 on bioaccumulation and responsiveness to environmental pollutants are still poorly explored, particularly in terms of cellular mechanisms. According to future projections of temperature and pH/pCO2, this study investigated the main cellular pathways involved in metal detoxification and oxidative homeostasis in Mediterranean mussels, Mytilus galloprovincialis, exposed for 4 weeks to various combinations of two levels of pH/pCO2 (8.2/400 µatm and 7.4/3000 µatm), temperature (20 and 25 °C), and cadmium addition (0 and 20 µg/L). Bioaccumulation was increased in metal exposed organisms but it was not further modulated by different temperature and pH/pCO2 combinations. However, interactions between temperature, pH and cadmium had significant effects on induction of metallothioneins, responses of the antioxidant system and the onset of oxidative damages, which was tissue dependent. Multiple stressors increased metallothioneins concentrations in the digestive gland revealing different oxidative effects: while temperature and cadmium enhanced glutathione-dependent antioxidant protection and capability to neutralize peroxyl radicals, the metal increased the accumulation of lipid peroxidation products under acidified conditions. Gills did not reveal specific effects for different combinations of factors, but a general stress condition was observed in this tissue after various treatments. Significant variations of immune system were mainly caused by increased temperature and low pH, while co-exposure to acidification and cadmium enhanced metal genotoxicity and the onset of permanent DNA damage in haemocytes. Elaboration of the whole biomarker data in a cellular hazard index, corroborated the synergistic effects of temperature and acidification which increased the toxicological effects of cadmium. The overall results confirmed that climate change could influence ecotoxicological effects of environmental contaminants, highlighting the importance of a better knowledge of cellular mechanisms to understand and predict responsiveness of marine organisms to such multiple stressors. |
| title | Indirect effects of climate changes on cadmium bioavailability and biological effects in the Mediterranean mussel Mytilus galloprovincialis |
| topic | Adriatic_Sea; Alkalinity, total; Alkalinity, total, standard deviation; Animalia; Aragonite saturation state; Aragonite saturation state, standard deviation; Benthic animals; Benthos; Bicarbonate ion; Bottles or small containers/Aquaria (<20 L); Cadmium; Cadmium, standard deviation; Calcite saturation state; Calcite saturation state, standard deviation; Calculated using CO2SYS; Calculated using seacarb after Nisumaa et al. (2010); Carbon, inorganic, dissolved; Carbonate ion; Carbonate system computation flag; Carbon dioxide; Catalase activity, per protein mass; Catalase activity, standard deviation; Coast and continental shelf; EXP; Experiment; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Glutathione, total, per unit wet mass; Glutathione, total, per unit wet mass, standard deviation; Glutathione reductase, per protein mass; Glutathione reductase, unit per protein mass, standard deviation; Glutathione S-transferase, activity per protein mass; Glutathione S-transferase, activity per protein mass, standard deviation; Granulocytes/Hyalinocytes ratio; Granulocytes/Hyalinocytes ratio, standard deviation; Hemocytes DNA strand breaks; Hemocytes DNA strand breaks, standard deviation; Hemocytes lysosomal membranes stability; Hemocytes lysosomal membranes stability, standard deviation; Hemocytes micronuclei frequency; Hemocytes micronuclei frequency, standard deviation; Incubation duration; Inorganic toxins; Laboratory experiment; Lipofuscin; Lipofuscin, standard deviation; Malondialdehyde, per wet mass; Malondialdehyde, per wet mass, standard deviation; Mediterranean Sea; Metallothionein, per protein mass; Metallothionein per protein, standard deviation; Mollusca; Mytilus galloprovincialis; Neutral lipids; Neutral lipids, standard deviation; OA-ICC; Ocean acidification; Ocean Acidification International Coordination Centre; Partial pressure of carbon dioxide, standard deviation; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); pH, NBS scale; pH, standard deviation; pH, total scale; Phagocytosis rate; Phagocytosis rate, standard deviation; Potentiometric; Potentiometric titration; Registration number of species; Salinity; Salinity, standard deviation; Sample code/label; Selenium dependent glutathione peroxidases activity, per protein mass; Selenium dependent glutathione peroxidases activity, unit per protein mass, standard deviation; Single species; Species; Temperate; Temperature; Temperature, water; Temperature, water, standard deviation; Total glutathione peroxidases activity, per protein mass; Total glutathione peroxidases activity, unit per protein mass, standard deviation; Total oxyradical scavenging capacity against hydroxyl radicals, unit per protein mass; Total oxyradical scavenging capacity against hydroxyl radicals, unit per protein mass, standard deviation; Total oxyradical scavenging capacity against peroxyl radicals, unit per protein mass; Total oxyradical scavenging capacity against peroxyl radicals, unit per protein mass, standard deviation; Treatment; Type; Uniform resource locator/link to reference |
| url | https://doi.org/10.1594/PANGAEA.872084 |