Prioritised pharmaceuticals in German estuaries and coastal waters in 2015/2016
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| Format: | Dataset Open Access |
| Sprache: | en |
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PANGAEA
2021
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| _version_ | 1867170105853476864 |
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| author | Kötke, Danijela Gandrass, Juergen Xie, Zhiyong Ebinghaus, Ralf |
| author_facet | Kötke, Danijela Gandrass, Juergen Xie, Zhiyong Ebinghaus, Ralf |
| collection | Datos científicos de ciencias marinas y ambientales |
| contents | In this study a target analysis approach with method detection limits down to 0.01 ng L−1 was developed in order to determine ultra-trace pharmaceuticals in seawater of the German coast and their estuaries. The selection of target analytes based on a prioritisation commissioned by the German Environmental Agency considering occurrence in German surface waters, production volumes and ecotoxicological data. Using ultra-high pressure liquid chromatography coupled to a triple quadrupole mass spectrometer equipped with an electrospray ionisation source 21 prioritised pharmaceuticals out of seven therapeutical classes (antibiotics, iodinated X-ray contrast media (ICM), analgesics, lipid reducers, antiepileptics, anticonvulsants, beta-blockers) have been detected in the low to medium ng L−1-range. The most frequently measured substance groups in the German Baltic Sea and German Bight are the ICM, represented by the non-ionic ICM iomeprol (German Bightmax: 207 ng L−1; Baltic Seamax: 34.5 ng L−1) and the ionic ICM amidotrizoic acid (German Bight: 86.9 ng L−1), respectively. The same pattern of substance distribution could be detected in the German Bight, the German Baltic Sea and their inflows with lower concentrations in the offshore region that are partly a result of dilution with marine water. Pharmaceuticals entering the estuaries and coastal regions are an environmental issue since data on the ecotoxicological effects on aquatic marine organisms is limited. Especially the antibiotics clarithromycin and sulfamethoxazole could be ecotoxicologically/environmentally critical. |
| format | Dataset Open Access |
| id | pangaea_https___doi_org_10_1594_PANGAEA_929500 |
| institution | PANGAEA |
| language | en |
| publishDate | 2021 |
| publisher | PANGAEA |
| record_format | pangaea |
| spellingShingle | Prioritised pharmaceuticals in German estuaries and coastal waters in 2015/2016 Kötke, Danijela Gandrass, Juergen Xie, Zhiyong Ebinghaus, Ralf Amidotrizoic acid; Bezafibrate; Campaign of event; Carbamazepine; Clarithromycin; Date/Time of event; DEPTH, water; Diclofenac; Erythromycin; Event label; German Bight, North Sea; Helmholtz-Zentrum Geesthacht, Institute of Coastal Research; HZG; Iohexol; Iomeprol; Iopamidol; Iopromide; Ioxitalamic acid; Latitude of event; Lincomycin; Longitude of event; LP20150529; LP20150529_Stat_E1; LP20150529_Stat_E2; LP20150529_Stat_E3; LP20150529_Stat_E4; LP20150529_Stat_E5; LP20150529_Stat_GB1; LP20150529_Stat_GB2; LP20150529_Stat_GB3; LP20150529_Stat_GB4; LP20150529_Stat_GB5; LP20150529_Stat_W1; LP20150529_Stat_W2; LP20150529_Stat_W3; LP20150529_Stat_W4; Ludwig Prandtl; Nadolol; Paracetamol; pH; Primidone; Propranolol; Roxithromycin; Salinity; SB1508; SB1508_Stat_BS1; SB1508_Stat_BS10; SB1508_Stat_BS11; SB1508_Stat_BS12; SB1508_Stat_BS13; SB1508_Stat_BS15; SB1508_Stat_BS16; SB1508_Stat_BS19; SB1508_Stat_BS2; SB1508_Stat_BS20; SB1508_Stat_BS21; SB1508_Stat_BS22; SB1508_Stat_BS3; SB1508_Stat_BS4; SB1508_Stat_BS5; SB1508_Stat_BS6; SB1508_Stat_BS7; SB1508_Stat_BS8; SB1508_Stat_BS9; SB1508_Stat_O1; SB1508_Stat_O2; SB1508_Stat_O3; SB1508_Stat_P1; SB1603; SB1603_Stat_BS11; SB1603_Stat_BS14; SB1603_Stat_BS15; SB1603_Stat_BS16; SB1603_Stat_BS17; SB1603_Stat_BS18; SB1603_Stat_BS19; SB1603_Stat_BS20; SB1603_Stat_BS21; SB1603_Stat_BS22; SB1603_Stat_BS4; SB1603_Stat_BS5; SB1603_Stat_BS6; SB1603_Stat_BS7; SB1603_Stat_BS8; SB1603_Stat_BS9; See description in dataset comment; Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS); Sulfadimethoxine; Sulfamethazine; Sulfamethoxazole; Temperature, water; Tiamulin; Water sample; WS In this study a target analysis approach with method detection limits down to 0.01 ng L−1 was developed in order to determine ultra-trace pharmaceuticals in seawater of the German coast and their estuaries. The selection of target analytes based on a prioritisation commissioned by the German Environmental Agency considering occurrence in German surface waters, production volumes and ecotoxicological data. Using ultra-high pressure liquid chromatography coupled to a triple quadrupole mass spectrometer equipped with an electrospray ionisation source 21 prioritised pharmaceuticals out of seven therapeutical classes (antibiotics, iodinated X-ray contrast media (ICM), analgesics, lipid reducers, antiepileptics, anticonvulsants, beta-blockers) have been detected in the low to medium ng L−1-range. The most frequently measured substance groups in the German Baltic Sea and German Bight are the ICM, represented by the non-ionic ICM iomeprol (German Bightmax: 207 ng L−1; Baltic Seamax: 34.5 ng L−1) and the ionic ICM amidotrizoic acid (German Bight: 86.9 ng L−1), respectively. The same pattern of substance distribution could be detected in the German Bight, the German Baltic Sea and their inflows with lower concentrations in the offshore region that are partly a result of dilution with marine water. Pharmaceuticals entering the estuaries and coastal regions are an environmental issue since data on the ecotoxicological effects on aquatic marine organisms is limited. Especially the antibiotics clarithromycin and sulfamethoxazole could be ecotoxicologically/environmentally critical. |
| title | Prioritised pharmaceuticals in German estuaries and coastal waters in 2015/2016 |
| topic | Amidotrizoic acid; Bezafibrate; Campaign of event; Carbamazepine; Clarithromycin; Date/Time of event; DEPTH, water; Diclofenac; Erythromycin; Event label; German Bight, North Sea; Helmholtz-Zentrum Geesthacht, Institute of Coastal Research; HZG; Iohexol; Iomeprol; Iopamidol; Iopromide; Ioxitalamic acid; Latitude of event; Lincomycin; Longitude of event; LP20150529; LP20150529_Stat_E1; LP20150529_Stat_E2; LP20150529_Stat_E3; LP20150529_Stat_E4; LP20150529_Stat_E5; LP20150529_Stat_GB1; LP20150529_Stat_GB2; LP20150529_Stat_GB3; LP20150529_Stat_GB4; LP20150529_Stat_GB5; LP20150529_Stat_W1; LP20150529_Stat_W2; LP20150529_Stat_W3; LP20150529_Stat_W4; Ludwig Prandtl; Nadolol; Paracetamol; pH; Primidone; Propranolol; Roxithromycin; Salinity; SB1508; SB1508_Stat_BS1; SB1508_Stat_BS10; SB1508_Stat_BS11; SB1508_Stat_BS12; SB1508_Stat_BS13; SB1508_Stat_BS15; SB1508_Stat_BS16; SB1508_Stat_BS19; SB1508_Stat_BS2; SB1508_Stat_BS20; SB1508_Stat_BS21; SB1508_Stat_BS22; SB1508_Stat_BS3; SB1508_Stat_BS4; SB1508_Stat_BS5; SB1508_Stat_BS6; SB1508_Stat_BS7; SB1508_Stat_BS8; SB1508_Stat_BS9; SB1508_Stat_O1; SB1508_Stat_O2; SB1508_Stat_O3; SB1508_Stat_P1; SB1603; SB1603_Stat_BS11; SB1603_Stat_BS14; SB1603_Stat_BS15; SB1603_Stat_BS16; SB1603_Stat_BS17; SB1603_Stat_BS18; SB1603_Stat_BS19; SB1603_Stat_BS20; SB1603_Stat_BS21; SB1603_Stat_BS22; SB1603_Stat_BS4; SB1603_Stat_BS5; SB1603_Stat_BS6; SB1603_Stat_BS7; SB1603_Stat_BS8; SB1603_Stat_BS9; See description in dataset comment; Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS); Sulfadimethoxine; Sulfamethazine; Sulfamethoxazole; Temperature, water; Tiamulin; Water sample; WS |
| url | https://doi.org/10.1594/PANGAEA.929500 |