Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus using OSMAC strategy.
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| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Frontiers in microbiology
2024
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| Acceso en línea: | |
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| author | Gao, Ying Frank, Marian Teusch, Nicole Woschko, Dennis Janiak, Christoph Mándi, Attila Kurtán, Tibor Hartmann, Rudolf Schiedlauske, Katja van Geelen, Lasse Kalscheuer, Rainer Kaiser, Jesko Gertzen, Christoph G W Gohlke, Holger Wang, Bin-Gui Proksch, Peter Liu, Zhen |
| author_facet | Gao, Ying Frank, Marian Teusch, Nicole Woschko, Dennis Janiak, Christoph Mándi, Attila Kurtán, Tibor Hartmann, Rudolf Schiedlauske, Katja van Geelen, Lasse Kalscheuer, Rainer Kaiser, Jesko Gertzen, Christoph G W Gohlke, Holger Wang, Bin-Gui Proksch, Peter Liu, Zhen Gao, Ying Frank, Marian Teusch, Nicole Woschko, Dennis Janiak, Christoph Mándi, Attila Kurtán, Tibor Hartmann, Rudolf Schiedlauske, Katja van Geelen, Lasse Kalscheuer, Rainer Kaiser, Jesko Gertzen, Christoph G W Gohlke, Holger Wang, Bin-Gui Proksch, Peter Liu, Zhen |
| collection | PubMed - marine biology |
| contents | Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus using OSMAC strategy. Gao, Ying Frank, Marian Teusch, Nicole Woschko, Dennis Janiak, Christoph Mándi, Attila Kurtán, Tibor Hartmann, Rudolf Schiedlauske, Katja van Geelen, Lasse Kalscheuer, Rainer Kaiser, Jesko Gertzen, Christoph G W Gohlke, Holger Wang, Bin-Gui Proksch, Peter Liu, Zhen Three sulfur-containing alkaloids aplospojaveedins A-C (1-3) with a hitherto undescribed carbon skeleton comprising octahy-dronaphthalene, , -unsaturated lactam and glycine-cysteine moieties were isolated from . Their structures were elucidated by 1D and 2D NMR spectroscopy, HR-MS, X-ray diffraction analysis, DFT-NMR and TDDFT-ECD calculations. A plausible biosynthetic pathway and putative targets are described. The blind docking suggested that 1-3 may have functional effects on several putative targets such as the GPCR cannabinoid receptor 2 or the integrin 51 complex. |
| format | Artículo científico |
| id | pubmed_39397793 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Frontiers in microbiology |
| record_format | pubmed |
| spellingShingle | Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus using OSMAC strategy. Gao, Ying Frank, Marian Teusch, Nicole Woschko, Dennis Janiak, Christoph Mándi, Attila Kurtán, Tibor Hartmann, Rudolf Schiedlauske, Katja van Geelen, Lasse Kalscheuer, Rainer Kaiser, Jesko Gertzen, Christoph G W Gohlke, Holger Wang, Bin-Gui Proksch, Peter Liu, Zhen Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus using OSMAC strategy. Gao, Ying Frank, Marian Teusch, Nicole Woschko, Dennis Janiak, Christoph Mándi, Attila Kurtán, Tibor Hartmann, Rudolf Schiedlauske, Katja van Geelen, Lasse Kalscheuer, Rainer Kaiser, Jesko Gertzen, Christoph G W Gohlke, Holger Wang, Bin-Gui Proksch, Peter Liu, Zhen Three sulfur-containing alkaloids aplospojaveedins A-C (1-3) with a hitherto undescribed carbon skeleton comprising octahy-dronaphthalene, , -unsaturated lactam and glycine-cysteine moieties were isolated from . Their structures were elucidated by 1D and 2D NMR spectroscopy, HR-MS, X-ray diffraction analysis, DFT-NMR and TDDFT-ECD calculations. A plausible biosynthetic pathway and putative targets are described. The blind docking suggested that 1-3 may have functional effects on several putative targets such as the GPCR cannabinoid receptor 2 or the integrin 51 complex. |
| title | Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus using OSMAC strategy. |
| url | https://pubmed.ncbi.nlm.nih.gov/39397793/ |