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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Molecules (Basel, Switzerland)
2024
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39407523/ |
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Table of Contents:
- Antimicrobial, Antioxidant and Anti-Inflammatory Activities of the Mucus of the Tropical Sea Slug . Lopes, Diana Cunha, Eva Conde, Tiago Moreira, Anthony Cruz, Sónia Domingues, Pedro Oliveira, Manuela Cartaxana, Paulo Animals Mucus Antioxidants Anti-Inflammatory Agents Gastropoda Anti-Infective Agents Microbial Sensitivity Tests Anti-Bacterial Agents (Sacoglossa, Gastropoda) is a tropical sea slug known for its ability to incorporate functional chloroplasts from a variety of green macroalgae, a phenomenon termed kleptoplasty. This sea slug, amenable to laboratory cultivation, produces mucus, a viscous secretion that serves diverse purposes including protection, locomotion, and reproduction. In this study, we profiled the antimicrobial, antioxidant, and anti-inflammatory activities of the mucus of this sea slug. Results revealed inhibitory activity against several bacterial strains, more pronounced for Gram-negative bacteria. Particularly interesting was the strong inhibitory effect against , a bacterial species classified by the WHO as a high-priority pathogen and associated with high-risk infections due to its frequent multidrug-resistant profile. Similar inhibitory effects were observed for the mucus native protein extracts, indicating that proteins present in the mucus contributed significantly to the antimicrobial activity. The mucus also showed both antioxidant and anti-inflammatory activities. The latter activities were associated with the low molecular weight (