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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine drugs
2024
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39452852/ |
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| author | Pham, Giang Nam Josselin, Béatrice Cousseau, Arnaud Baratte, Blandine Dayras, Marie Le Meur, Christophe Debaets, Stella Weill, Amélie Robert, Thomas Burgaud, Gaëtan Probert, Ian Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Bach, Stéphane Mehiri, Mohamed |
| author_facet | Pham, Giang Nam Josselin, Béatrice Cousseau, Arnaud Baratte, Blandine Dayras, Marie Le Meur, Christophe Debaets, Stella Weill, Amélie Robert, Thomas Burgaud, Gaëtan Probert, Ian Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Bach, Stéphane Mehiri, Mohamed Pham, Giang Nam Josselin, Béatrice Cousseau, Arnaud Baratte, Blandine Dayras, Marie Le Meur, Christophe Debaets, Stella Weill, Amélie Robert, Thomas Burgaud, Gaëtan Probert, Ian Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Bach, Stéphane Mehiri, Mohamed |
| collection | PubMed - marine biology |
| contents | New Fusarochromanone Derivatives from the Marine Fungus UBOCC-A-117302. Pham, Giang Nam Josselin, Béatrice Cousseau, Arnaud Baratte, Blandine Dayras, Marie Le Meur, Christophe Debaets, Stella Weill, Amélie Robert, Thomas Burgaud, Gaëtan Probert, Ian Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Bach, Stéphane Mehiri, Mohamed Fusarium Humans Chromones Cell Line, Tumor Microbial Sensitivity Tests Anti-Bacterial Agents Antineoplastic Agents Aquatic Organisms Protein Kinase Inhibitors Two new fusarochromanone derivatives, deacetylfusarochromene () and deacetamidofusarochrom-2',3-diene (), along with the previously reported metabolites fusarochromanone TDP-2 (), fusarochromene (), 2,2-dimethyl-5-amino-6-(2'-ene-4'-hydroxylbutyryl)-4-chromone (), fusarochromanone (), (-)-chrysogine (), and equisetin (), were isolated from the marine fungus UBOCC-A-117302. The structures of the compounds were determined by extensive spectrometric (HRMS) and spectroscopic (1D and 2D NMR) analyses, as well as specific rotation. Among them, and showed inhibition of three protein kinases with IC values ranging from 1.42 to 25.48 μM. Cytotoxicity and antimicrobial activity of all isolated compounds were also evaluated. Six fusarochromanone derivatives (-) exhibited diverse activities against three cell lines, RPE-1, HCT-116, and U2OS (IC values ranging from 0.058 to 84.380 μM). Equisetin () showed bactericidal activities against and (MBC values of 7.8 and 31.25 µM, respectively), and bacteriostatic activity against (MIC value of 31.25 µM). Compounds and showed bacteriostatic activities against (MIC of 125 µM). |
| format | Artículo científico |
| id | pubmed_39452852 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | New Fusarochromanone Derivatives from the Marine Fungus UBOCC-A-117302. Pham, Giang Nam Josselin, Béatrice Cousseau, Arnaud Baratte, Blandine Dayras, Marie Le Meur, Christophe Debaets, Stella Weill, Amélie Robert, Thomas Burgaud, Gaëtan Probert, Ian Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Bach, Stéphane Mehiri, Mohamed Fusarium Humans Chromones Cell Line, Tumor Microbial Sensitivity Tests Anti-Bacterial Agents Antineoplastic Agents Aquatic Organisms Protein Kinase Inhibitors New Fusarochromanone Derivatives from the Marine Fungus UBOCC-A-117302. Pham, Giang Nam Josselin, Béatrice Cousseau, Arnaud Baratte, Blandine Dayras, Marie Le Meur, Christophe Debaets, Stella Weill, Amélie Robert, Thomas Burgaud, Gaëtan Probert, Ian Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Bach, Stéphane Mehiri, Mohamed Fusarium Humans Chromones Cell Line, Tumor Microbial Sensitivity Tests Anti-Bacterial Agents Antineoplastic Agents Aquatic Organisms Protein Kinase Inhibitors Two new fusarochromanone derivatives, deacetylfusarochromene () and deacetamidofusarochrom-2',3-diene (), along with the previously reported metabolites fusarochromanone TDP-2 (), fusarochromene (), 2,2-dimethyl-5-amino-6-(2'-ene-4'-hydroxylbutyryl)-4-chromone (), fusarochromanone (), (-)-chrysogine (), and equisetin (), were isolated from the marine fungus UBOCC-A-117302. The structures of the compounds were determined by extensive spectrometric (HRMS) and spectroscopic (1D and 2D NMR) analyses, as well as specific rotation. Among them, and showed inhibition of three protein kinases with IC values ranging from 1.42 to 25.48 μM. Cytotoxicity and antimicrobial activity of all isolated compounds were also evaluated. Six fusarochromanone derivatives (-) exhibited diverse activities against three cell lines, RPE-1, HCT-116, and U2OS (IC values ranging from 0.058 to 84.380 μM). Equisetin () showed bactericidal activities against and (MBC values of 7.8 and 31.25 µM, respectively), and bacteriostatic activity against (MIC value of 31.25 µM). Compounds and showed bacteriostatic activities against (MIC of 125 µM). |
| title | New Fusarochromanone Derivatives from the Marine Fungus UBOCC-A-117302. |
| topic | Fusarium Humans Chromones Cell Line, Tumor Microbial Sensitivity Tests Anti-Bacterial Agents Antineoplastic Agents Aquatic Organisms Protein Kinase Inhibitors |
| url | https://pubmed.ncbi.nlm.nih.gov/39452852/ |