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| Main Authors: | , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine drugs
2024
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39452885/ |
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| _version_ | 1868266287744942081 |
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| author | Liu, Xiaojing Wang, Qi Zhang, Yun Zhang, Hanting |
| author_facet | Liu, Xiaojing Wang, Qi Zhang, Yun Zhang, Hanting Liu, Xiaojing Wang, Qi Zhang, Yun Zhang, Hanting |
| collection | PubMed - marine biology |
| contents | Discovery of Anti-Inflammatory Alkaloids from Sponge Suggests New Biosynthetic Pathways for Pyrrole-Imidazole Alkaloids. Liu, Xiaojing Wang, Qi Zhang, Yun Zhang, Hanting Animals Porifera Alkaloids Pyrroles Imidazoles Anti-Inflammatory Agents Zebrafish Biosynthetic Pathways Inflammation Molecular Structure Pyrrole-imidazole alkaloids (PIAs) are a class of marine sponge derived natural products which have complex carbon frameworks and broad bioactivities. In this study, four new alkaloids, stylimassalins A-B (-), , and , together with two known compounds ( and ), were isolated from . Compounds , , and are the C-2 brominated analogues of , , and , respectively. Their structures display three different scaffolds, of which scaffold 1 (compounds ,) is new. A new biosynthetic pathway from oroidin, through spongiacidin, to latonduine and scaffold 1 was proposed by our group, in which the C12-N13-cleavaged compounds of spongiacidin (scaffold 2), dubbed seco-spongiacidins ( and ), are recognized as a key bridged scaffold, to afford PIA analogues (, and ,). An anti-inflammatory evaluation in a zebrafish inflammation model induced by copper sulphate (CuSO) demonstrated that stylimassalins A and B ( and ) could serve as a promising lead scaffold for treating inflammation. |
| format | Artículo científico |
| id | pubmed_39452885 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | Discovery of Anti-Inflammatory Alkaloids from Sponge Suggests New Biosynthetic Pathways for Pyrrole-Imidazole Alkaloids. Liu, Xiaojing Wang, Qi Zhang, Yun Zhang, Hanting Animals Porifera Alkaloids Pyrroles Imidazoles Anti-Inflammatory Agents Zebrafish Biosynthetic Pathways Inflammation Molecular Structure Discovery of Anti-Inflammatory Alkaloids from Sponge Suggests New Biosynthetic Pathways for Pyrrole-Imidazole Alkaloids. Liu, Xiaojing Wang, Qi Zhang, Yun Zhang, Hanting Animals Porifera Alkaloids Pyrroles Imidazoles Anti-Inflammatory Agents Zebrafish Biosynthetic Pathways Inflammation Molecular Structure Pyrrole-imidazole alkaloids (PIAs) are a class of marine sponge derived natural products which have complex carbon frameworks and broad bioactivities. In this study, four new alkaloids, stylimassalins A-B (-), , and , together with two known compounds ( and ), were isolated from . Compounds , , and are the C-2 brominated analogues of , , and , respectively. Their structures display three different scaffolds, of which scaffold 1 (compounds ,) is new. A new biosynthetic pathway from oroidin, through spongiacidin, to latonduine and scaffold 1 was proposed by our group, in which the C12-N13-cleavaged compounds of spongiacidin (scaffold 2), dubbed seco-spongiacidins ( and ), are recognized as a key bridged scaffold, to afford PIA analogues (, and ,). An anti-inflammatory evaluation in a zebrafish inflammation model induced by copper sulphate (CuSO) demonstrated that stylimassalins A and B ( and ) could serve as a promising lead scaffold for treating inflammation. |
| title | Discovery of Anti-Inflammatory Alkaloids from Sponge Suggests New Biosynthetic Pathways for Pyrrole-Imidazole Alkaloids. |
| topic | Animals Porifera Alkaloids Pyrroles Imidazoles Anti-Inflammatory Agents Zebrafish Biosynthetic Pathways Inflammation Molecular Structure |
| url | https://pubmed.ncbi.nlm.nih.gov/39452885/ |