Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine drugs
2024
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39452885/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Discovery of Anti-Inflammatory Alkaloids from Sponge Suggests New Biosynthetic Pathways for Pyrrole-Imidazole Alkaloids. Liu, Xiaojing Wang, Qi Zhang, Yun Zhang, Hanting Animals Porifera Alkaloids Pyrroles Imidazoles Anti-Inflammatory Agents Zebrafish Biosynthetic Pathways Inflammation Molecular Structure Pyrrole-imidazole alkaloids (PIAs) are a class of marine sponge derived natural products which have complex carbon frameworks and broad bioactivities. In this study, four new alkaloids, stylimassalins A-B (-), , and , together with two known compounds ( and ), were isolated from . Compounds , , and are the C-2 brominated analogues of , , and , respectively. Their structures display three different scaffolds, of which scaffold 1 (compounds ,) is new. A new biosynthetic pathway from oroidin, through spongiacidin, to latonduine and scaffold 1 was proposed by our group, in which the C12-N13-cleavaged compounds of spongiacidin (scaffold 2), dubbed seco-spongiacidins ( and ), are recognized as a key bridged scaffold, to afford PIA analogues (, and ,). An anti-inflammatory evaluation in a zebrafish inflammation model induced by copper sulphate (CuSO) demonstrated that stylimassalins A and B ( and ) could serve as a promising lead scaffold for treating inflammation.