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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Veterinary sciences
2024
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39453056/ |
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| _version_ | 1868266287744942080 |
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| author | Zhu, Zhen Wu, Jiang Wen, Yuguo Wu, Xiaocheng Bao, Huimingda Wang, Min Kang, Kai |
| author_facet | Zhu, Zhen Wu, Jiang Wen, Yuguo Wu, Xiaocheng Bao, Huimingda Wang, Min Kang, Kai Zhu, Zhen Wu, Jiang Wen, Yuguo Wu, Xiaocheng Bao, Huimingda Wang, Min Kang, Kai |
| collection | PubMed - marine biology |
| contents | Advances in the Effects of Heat Stress on Ovarian Granulosa Cells: Unveiling Novel Ferroptosis Pathways. Zhu, Zhen Wu, Jiang Wen, Yuguo Wu, Xiaocheng Bao, Huimingda Wang, Min Kang, Kai Heat stress has been one of the key research areas for researchers due to the wide-ranging effects and complex mechanisms of action of its stress product reactive oxygen species (ROS). The aim of this paper is to comprehensively review and summarize the effects of heat stress on ovarian granulosa cells and their mechanism of action. We systematically reviewed the effects of heat stress on ovarian granulosa cells, including intracellular steroid hormone changes, oxidative stress, apoptosis, and mitochondrial function. Meanwhile, this paper discusses in detail several major mechanisms by which heat stress induces apoptosis in ovarian granulosa cells, such as through the activation of apoptosis-related genes, induction of endoplasmic reticulum stress, and the mitochondrial pathway. In addition, we analyzed the mechanism of ferroptosis in ovarian granulosa cells under heat stress conditions, summarized the potential association between heat stress and ferroptosis in light of the existing literature, and explored the key factors in the mechanism of action of heat stress, such as the signaling pathways of Nrf2/Keap1, HSPs, and JNK, and analyzed their possible roles in the process of ferroptosis. Finally, this paper provides an outlook on the future research direction, describing the possible interaction between heat stress and ferroptosis, with a view to providing a theoretical basis for further understanding and revealing the complex mechanism of ferroptosis occurrence in ovarian granulosa cells under heat stress. |
| format | Artículo científico |
| id | pubmed_39453056 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Veterinary sciences |
| record_format | pubmed |
| spellingShingle | Advances in the Effects of Heat Stress on Ovarian Granulosa Cells: Unveiling Novel Ferroptosis Pathways. Zhu, Zhen Wu, Jiang Wen, Yuguo Wu, Xiaocheng Bao, Huimingda Wang, Min Kang, Kai Advances in the Effects of Heat Stress on Ovarian Granulosa Cells: Unveiling Novel Ferroptosis Pathways. Zhu, Zhen Wu, Jiang Wen, Yuguo Wu, Xiaocheng Bao, Huimingda Wang, Min Kang, Kai Heat stress has been one of the key research areas for researchers due to the wide-ranging effects and complex mechanisms of action of its stress product reactive oxygen species (ROS). The aim of this paper is to comprehensively review and summarize the effects of heat stress on ovarian granulosa cells and their mechanism of action. We systematically reviewed the effects of heat stress on ovarian granulosa cells, including intracellular steroid hormone changes, oxidative stress, apoptosis, and mitochondrial function. Meanwhile, this paper discusses in detail several major mechanisms by which heat stress induces apoptosis in ovarian granulosa cells, such as through the activation of apoptosis-related genes, induction of endoplasmic reticulum stress, and the mitochondrial pathway. In addition, we analyzed the mechanism of ferroptosis in ovarian granulosa cells under heat stress conditions, summarized the potential association between heat stress and ferroptosis in light of the existing literature, and explored the key factors in the mechanism of action of heat stress, such as the signaling pathways of Nrf2/Keap1, HSPs, and JNK, and analyzed their possible roles in the process of ferroptosis. Finally, this paper provides an outlook on the future research direction, describing the possible interaction between heat stress and ferroptosis, with a view to providing a theoretical basis for further understanding and revealing the complex mechanism of ferroptosis occurrence in ovarian granulosa cells under heat stress. |
| title | Advances in the Effects of Heat Stress on Ovarian Granulosa Cells: Unveiling Novel Ferroptosis Pathways. |
| url | https://pubmed.ncbi.nlm.nih.gov/39453056/ |